Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 6/20 | 0.36 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17683321 | 1.00 | DYRK1A (0.44) | DYRK1ADYRK1BMKNK1MKNK2EGFR | |
| SCHEMBL30337183 | 0.90 | DYRK1A (0.41) | DYRK1ADYRK1BMKNK1MKNK2EGFR | |
| SCHEMBL28987580 | 0.90 | DYRK1A (0.41) | DYRK1ADYRK1BMKNK1MKNK2EGFR | |
| SCHEMBL28384419 | 0.86 | DYRK1A (0.46) | DYRK1ADYRK1BMKNK1MKNK2EGFR | |
| SCHEMBL30337162 | 0.86 | DYRK1A (0.46) | DYRK1ADYRK1BMKNK1MKNK2EGFR | |
| SCHEMBL30337212 | 0.85 | DYRK1A (0.45) | DYRK1ADYRK1BMKNK1MKNK2EGFR | |
| SCHEMBL19254846 | 0.85 | DYRK1A (0.45) | DYRK1ADYRK1BMKNK1MKNK2EGFR | |
| SCHEMBL17490471 | 0.85 | DYRK1A (0.45) | DYRK1ADYRK1BMKNK1MKNK2EGFR | |
| SCHEMBL28987593 | 0.82 | DYRK1A (0.44) | DYRK1ADYRK1BMKNK1MKNK2EGFR | |
| SCHEMBL30337177 | 0.82 | DYRK1A (0.44) | DYRK1ADYRK1BMKNK1MKNK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117402143-A | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-117069700-A | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-11-17 | — | — | CN | disclosed |
| CN-111187221-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-09-26 | — | — | CN | disclosed |
| CN-111171000-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-111170999-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-06-30 | — | — | CN | disclosed |