Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.56 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17683156 | 1.00 | FGFR1 (0.56) | FGFR1IRAK4ROCK1ALDH1A1MAPT | |
| SCHEMBL6039505 | 0.82 | MAP3K14 (0.58) | FGFR1IRAK4ROCK1RPS6KA5MAP3K14 | |
| SCHEMBL5765710 | 0.78 | FGFR1 (0.54) | FGFR1IRAK4ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL20548967 | 0.77 | ROCK1 (0.72) | ROCK1MAPTRPS6KA5MAP3K14 | |
| SCHEMBL6039615 | 0.76 | ROCK1 (0.68) | ROCK1RPS6KA5LCKMKNK1MKNK2 | |
| SCHEMBL4590705 | 0.75 | FGFR1 (0.74) | FGFR1ALDH1A1MAPTSMN1; SMN2KDR | |
| SCHEMBL7014066 | 0.74 | LCK (0.76) | FGFR1LCKMKNK1MKNK2 | |
| SCHEMBL21980701 | 0.73 | GRM2 (0.44) | ROCK1 | |
| SCHEMBL6039398 | 0.73 | MAP3K14 (0.74) | FGFR1IRAK4ROCK1RPS6KA5MAP3K14 | |
| SCHEMBL19848358 | 0.73 | FGFR1 (0.76) | FGFR1ALDH1A1MAPTSMN1; SMN2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117402143-A | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-117069700-A | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-11-17 | — | — | CN | disclosed |
| CN-111187221-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-09-26 | — | — | CN | disclosed |
| CN-111171000-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-111170999-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-06-30 | — | — | CN | disclosed |