Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.49 |
| ▸ | CDK1 | P06493 | 2/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.49 |
| ▸ | CDK9 | P50750 | 2/20 | 0.49 |
| ▸ | CDK7 | P50613 | 1/20 | 0.49 |
| ▸ | CCNH | P51946 | 1/20 | 0.49 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17683140 | 1.00 | MKNK1 (0.51) | MKNK1MKNK2MAPK8MAPK9MAPK10 | |
| SCHEMBL19100812 | 0.83 | MKNK2 (0.41) | MKNK1MKNK2MAPK8MAPK9MAPK10 | |
| SCHEMBL19100800 | 0.83 | MKNK1 (0.41) | MKNK1MKNK2MAPK8MAPK9MAPK10 | |
| SCHEMBL19100862 | 0.81 | RPS6KA5 (0.58) | MKNK1MKNK2MAPK8MAPK9MAPK10 | |
| SCHEMBL12489602 | 0.81 | CDC7 (0.56) | MKNK1MKNK2MAPK8MAPK9MAPK10 | |
| SCHEMBL19100208 | 0.79 | KDM4E (0.55) | MKNK1MKNK2MAPK8MAPK9MAPK10 | |
| SCHEMBL29695764 | 0.79 | CHEK1 (0.41) | CCNT1CDK1CCNB1CDK9CDK7 | |
| SCHEMBL17683358 | 0.79 | CYP11B1 (0.43) | RPS6KA5IRAK4CYP11B1CYP11B2PAK4 | |
| SCHEMBL3824181 | 0.77 | MKNK1 (0.48) | MKNK1MKNK2MAPK8MAPK9MAPK10 | |
| SCHEMBL12075159 | 0.77 | MKNK1 (0.46) | MKNK1MKNK2MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117402143-A | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-117069700-A | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-11-17 | — | — | CN | disclosed |
| CN-111187221-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-09-26 | — | — | CN | disclosed |
| CN-111171000-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-111170999-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-06-30 | — | — | CN | disclosed |