Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | NEK2 | P51955 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30460166 | 0.95 | EGFR (0.44) | EGFRLCK | |
| SCHEMBL30460426 | 0.88 | EGFR (0.45) | EGFRLCKSRCKDRMAPK14 | |
| SCHEMBL30459911 | 0.87 | EGFR (0.43) | EGFRLCKSRCKDRMAPK14 | |
| SCHEMBL30459808 | 0.87 | EGFR (0.46) | EGFRKDR | |
| SCHEMBL17683202 | 0.85 | EGFR (0.61) | EGFRKDR | |
| SCHEMBL19540678 | 0.83 | EGFR (0.47) | EGFR | |
| SCHEMBL30459962 | 0.81 | MAPK8 (0.46) | EGFRKDR | |
| SCHEMBL19254491 | 0.80 | EGFR (0.47) | EGFR | |
| SCHEMBL17683192 | 0.80 | EGFR (0.61) | EGFRKDR | |
| SCHEMBL21980692 | 0.79 | EGFR (0.46) | EGFRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117402143-A | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-117069700-A | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-11-17 | — | — | CN | disclosed |
| CN-111187221-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-09-26 | — | — | CN | disclosed |
| CN-111171000-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-111170999-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-06-30 | — | — | CN | disclosed |