Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 6/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | FGB | P02675 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29041890 | 1.00 | PGR (0.51) | PGRPDE3BPDE3APDK2PDK4 | |
| SCHEMBL16321516 | 0.88 | MAPK14 (0.53) | PGRPDK2PDK4LMNAALDH1A1 | |
| SCHEMBL29825095 | 0.88 | MAPK14 (0.53) | PGRPDK2PDK4LMNAALDH1A1 | |
| SCHEMBL4904403 | 0.83 | IP6K1 (0.45) | PDK2IP6K1LMNAALDH1A1MAPT | |
| SCHEMBL1874397 | 0.82 | PGR (0.55) | PGRPDE3BPDE3APDK2PDK4 | |
| SCHEMBL25156270 | 0.80 | MAPK14 (0.43) | PGRPDE3BPDE3APDK2PDK4 | |
| SCHEMBL12548325 | 0.79 | IP6K1 (0.57) | PGRPDE3BPDE3AIP6K1LMNA | |
| SCHEMBL7379550 | 0.78 | PGR (0.51) | PGRPDE3BPDE3APDK2PDK4 | |
| SCHEMBL31117105 | 0.78 | PGR (0.51) | PGRPDE3BPDE3APDK2PDK4 | |
| SCHEMBL22711811 | 0.77 | IP6K1 (0.56) | IP6K1LMNAALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116457346-A | Preparation of indolone derivatives as novel diacylglycerol O-acyltransferase 2 inhibitors | 默沙东有限责任公司 | 2023-07-18 | — | — | CN | disclosed |