Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.48 |
| ▸ | CDK4 | P11802 | 2/20 | 0.48 |
| ▸ | CCND1 | P24385 | 2/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | NT5E | P21589 | 4/20 | 0.44 |
| ▸ | PDE2A | O00408 | 2/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25288075 | 1.00 | KDM4E (0.50) | KDM4EALDH1A1HPGDHSD17B10CCNE2 | |
| SCHEMBL12961030 | 0.83 | ADRB2 (0.57) | KDM4ENT5EADRB2ADRA2AHTR2C | |
| SCHEMBL26406182 | 0.80 | CCNE2 (0.44) | KDM4EALDH1A1HSD17B10CCNE2CDK4 | |
| SCHEMBL15487038 | 0.80 | ESR2 (0.55) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL30460713 | 0.78 | NT5E (0.58) | KDM4EALDH1A1HPGDHSD17B10CDK2 | |
| SCHEMBL25245924 | 0.78 | NT5E (0.58) | KDM4EALDH1A1HPGDHSD17B10CDK2 | |
| SCHEMBL423741 | 0.77 | CYP1A2 (0.58) | KDM4EALDH1A1HPGDADRB2ADORA2A | |
| SCHEMBL31473229 | 0.77 | CYP1A2 (0.58) | KDM4EALDH1A1HPGDADRB2ADORA2A | |
| SCHEMBL15472861 | 0.77 | KDM4E (0.57) | KDM4EALDH1A1HPGDHSD17B10CCNE2 | |
| SCHEMBL12247506 | 0.77 | KDM4E (0.57) | KDM4EALDH1A1HPGDHSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4458820-A1 | CLASS OF QUINOLINE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2024-11-06 | — | — | EP | disclosed |
| CN-118871435-A | Quinoline compound, preparation method, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2024-10-29 | — | — | CN | disclosed |
| CN-116354934-A | Quinoline compound, preparation method, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2023-06-30 | — | — | CN | disclosed |