Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.65 |
| ▸ | KDR | P35968 | 6/20 | 0.65 |
| ▸ | CDK1 | P06493 | 1/20 | 0.65 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.45 |
| ▸ | WEE1 | P30291 | 2/20 | 0.45 |
| ▸ | PRKCA | P17252 | 2/20 | 0.41 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | GLI1 | P08151 | 1/20 | 0.39 |
| ▸ | GLI2 | P10070 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3040225 | 0.87 | AURKA (0.49) | AURKAKDRCDK1ROCK2WEE1 | |
| SCHEMBL3047764 | 0.86 | KDR (0.49) | AURKAKDRCDK1WEE1 | |
| Hydrochloric Acid SCHEMBL3050705 | 0.86 | AURKA (0.48) | AURKAKDRCDK1ROCK2WEE1 | |
| SCHEMBL3033775 | 0.85 | KDR (0.63) | AURKAKDRCDK1ROCK2WEE1 | |
| SCHEMBL3051471 | 0.84 | AURKA (0.47) | AURKAKDRCDK1CDK5CDK5R1 | |
| Hydrochloric Acid SCHEMBL3038378 | 0.80 | AURKA (0.43) | AURKAKDRCDK1PRKCAPRKCQ | |
| SCHEMBL3047573 | 0.80 | KDR (0.46) | AURKAKDRCDK1CHEK1 | |
| SCHEMBL3041519 | 0.79 | HPGD (0.45) | AURKAKDRCDK1 | |
| Hydrochloric Acid SCHEMBL3050162 | 0.79 | AURKA (0.43) | AURKAKDRCDK1WEE1 | |
| SCHEMBL3042431 | 0.79 | KDR (0.45) | AURKAKDRCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745641-B2 | Nitrogen-containing heterocyclic compound | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-06-29 | — | — | US | disclosed |
| US-20090054407-A1 | Nitrogen-containing heterocyclic compound | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-02-26 | — | — | US | disclosed |
| EP-1880993-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2008-01-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054407-A1 | Nitrogen-containing heterocyclic compound | NR4A1, NR5A2, PRMT8 | AURKA 2312/4885KDR 3226/4885CDK1 922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.