Sugi Predict

Sugi Predict / Targets / PRMT8

PRMT8

Protein arginine N-methyltransferase 8 · Q9NR22 · PRMT8 on Sugi Atlas →

13,687 patent compounds predicted against PRMT8, 8,248 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1045046 SCHEMBL1045046 0.79 3/20
SCHEMBL1108189 SCHEMBL1108189 0.67 3/20
SCHEMBL1579206 SCHEMBL1579206 0.62 3/20
SCHEMBL39876 SCHEMBL39876 0.58 3/20
SCHEMBL991339 SCHEMBL991339 0.54 3/20
SCHEMBL1574274 SCHEMBL1574274 0.49 3/20
SCHEMBL1238599 SCHEMBL1238599 0.40 3/20
SCHEMBL77007 SCHEMBL77007 0.95 2/20
SCHEMBL821483 SCHEMBL821483 0.77 2/20
SCHEMBL1267683 SCHEMBL1267683 0.73 2/20
SCHEMBL1268626 SCHEMBL1268626 0.70 2/20
SCHEMBL39802 SCHEMBL39802 0.62 2/20
SCHEMBL681608 SCHEMBL681608 0.62 2/20
SCHEMBL991338 SCHEMBL991338 0.62 2/20
SCHEMBL821417 SCHEMBL821417 0.58 2/20
SCHEMBL821485 SCHEMBL821485 0.57 2/20
SCHEMBL242420 SCHEMBL242420 0.56 2/20
Iodide Iodide (SCHEMBL872878) 0.55 2/20
SCHEMBL822087 SCHEMBL822087 0.55 2/20
SCHEMBL821447 SCHEMBL821447 0.55 2/20

Clinical trials — most relevant to PRMT8 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
A Phase 1/2/3 Study of TSHA-102 Gene Therapy in Females With Rett Syndrome (REVEAL Pivotal Study) PHASE3RECRUITING
Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor PHASE1/PHASE2NOT_YET_RECRUITING
A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors PHASE1/PHASE2RECRUITING
Effect of Arginine- and Glutamine-based Oral Formulations on Salivary Biomarkers and Clinical Severity of Radiation-induced Oral Mucositis in Head and Neck Cancer: A Randomized Controlled Trial PHASE2COMPLETED
Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent, in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage Mesothelioma PHASE2SUSPENDED
Treatment With Azacitidine of Recurrent Gliomas With IDH1/2 Mutation PHASE2UNKNOWN
An Investigational Study of BGB-58067 As a Single Agent and in Combination With Anticancer Agents in Participants With Advanced Solid Tumors PHASE1RECRUITING
Phase I Trial of 4'-Thio-2'-Deoxycytidine (TdCyd) in Patients With Advanced Solid Tumors PHASE1COMPLETED
5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors PHASE1RECRUITING
Study of Cytolytic Viral Activation Therapy (CVAT) for Recurrent/Metastatic Nasopharyngeal Carcinoma PHASE1UNKNOWN
Single-Dose AAV-MECP2 Safety/Tolerability and Efficacy in Rett Syndrome EARLY_PHASE1ACTIVE_NOT_RECRUITING
Chemoprevention of Head and Neck Squamous Cell Carcinoma (HNSCC) With Valproic Acid EARLY_PHASE1COMPLETED
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients nanCOMPLETED
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD nanUNKNOWN
The Correlation Between Serum PRMT5 Level and Cardiac Ultrasound Indicators in Patients With Heart Failure nanENROLLING_BY_INVITATION
Patient's Derived Organoids for Drug Screening in Glioblastoma nanNOT_YET_RECRUITING
Markers of Cardiovascular Risk in Patients With Premature Coronary Artery Disease and Treatment nanUNKNOWN
The Molecular Pathogenesis Study of Cataract nanUNKNOWN
DNA Methylation and Perioperative Pain Treatment nanCOMPLETED
Study of the Articular Microbiota in Rheumatoid Arthritis. nanCOMPLETED
Glucagon Like Peptide-1 in Remote Ischemic Conditioning nanCOMPLETED
Studying The Role of Key Epigenetic Mediators in Breast Cancer Patients nanRECRUITING
Patients With RETT Syndrome nanUNKNOWN
Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD nanCOMPLETED
Mechanisms of Immune Deficiency nanUNKNOWN
Target of Suv420h1/2 in Hepatocytes nanRECRUITING
Impact of Weight Loss on the Human Sperm Epitranscriptome nanACTIVE_NOT_RECRUITING
Epitranscriptomic Blood Biomarkers for Coronary Artery Disease - A Prospective Cohort Study (IHD-EPITRAN) nanUNKNOWN
A Study of Multilocus Methylation Abnormalities in Subjects With Imprinting Disorders nanNOT_YET_RECRUITING
Scottish Advanced Fetal Research Study nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a PRMT8 binder may also engage these)

ProteinNameSimilarity
Q6PAK3 — 1.000 Q6PAK3 →
Q8AV13 — 0.999 Q8AV13 →
Q5RGQ2 — 0.998 Q5RGQ2 →
PRMT1 Protein arginine N-methyltransferase 1 0.995 landscape →
Q6VRB0 — 0.994 Q6VRB0 →
Q9JIF0 — 0.994 Q9JIF0 →
Q63009 — 0.993 Q63009 →
Q9U2X0 — 0.989 Q9U2X0 →
O82210 — 0.987 O82210 →
Q0J2C6 — 0.987 Q0J2C6 →
Q28F07 — 0.987 Q28F07 →
Q54EF2 — 0.986 Q54EF2 →
Q9SU94 — 0.986 Q9SU94 →
Q9URX7 — 0.985 Q9URX7 →
Q5ZIB9 — 0.985 Q5ZIB9 →
A2Z0C0 — 0.984 A2Z0C0 →
D9IVE5 — 0.982 D9IVE5 →
B3M1E1 — 0.982 B3M1E1 →
A8IEF3 — 0.981 A8IEF3 →
Q6PCI6 — 0.980 Q6PCI6 →
B3P4N5 — 0.980 B3P4N5 →
A2AV36 — 0.979 A2AV36 →
B3DLB3 — 0.979 B3DLB3 →
P38074 — 0.979 P38074 →
B4PVH6 — 0.979 B4PVH6 →
B4KA23 — 0.978 B4KA23 →
O70467 — 0.977 O70467 →
B4GZ20 — 0.977 B4GZ20 →
Q29B63 — 0.977 Q29B63 →
B4LVS8 — 0.977 B4LVS8 →