Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 14/20 | 0.85 |
| ▸ | ESR1 | P03372 | 2/20 | 0.64 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.64 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.64 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.64 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.64 |
| ▸ | SHBG | P04278 | 1/20 | 0.64 |
| ▸ | PGR | P06401 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.64 |
| ▸ | AR | P10275 | 1/20 | 0.64 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.64 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.64 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.64 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.64 |
| ▸ | PDE4A | P27815 | 1/20 | 0.64 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3178837 | 1.00 | STS (0.85) | STSESR1ESR2SLC22A2NR1I2 | |
| SCHEMBL3178828 | 1.00 | STS (0.85) | STSESR1ESR2SLC22A2NR1I2 | |
| SCHEMBL3046316 | 1.00 | STS (0.85) | STSESR1ESR2SLC22A2NR1I2 | |
| SCHEMBL3051244 | 0.96 | STS (0.84) | STSESR1ESR2SLC22A2NR1I2 | |
| SCHEMBL13478102 | 0.96 | STS (0.84) | STSESR1ESR2SLC22A2NR1I2 | |
| SCHEMBL3051243 | 0.96 | STS (0.84) | STSESR1ESR2SLC22A2NR1I2 | |
| SCHEMBL31508217 | 0.92 | STS (0.81) | STSESR1ESR2SLC22A2NR1I2 | |
| SCHEMBL6696338 | 0.89 | STS (0.69) | STSESR1 | |
| SCHEMBL27574592 | 0.89 | STS (0.69) | STSESR1 | |
| SCHEMBL486651 | 0.87 | STS (0.79) | STSESR1ESR2SLC22A2NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8357675-B2 | 17-alpha-substituted derivatives of estradiol with wound-healing activity | EUTICALS S.P.A. (IT) | 2013-01-22 | — | — | US | disclosed |
| EP-1910398-B1 | 17-ALPHA-SUBSTITUTED DERIVATIVES OF ESTRADIOL WITH WOUND-HEALING ACTIVITY | PRIME EUROP THERAPEUTICALS (IT) | 2010-11-24 | — | — | EP | disclosed |
| US-20100035796-A1 | 17-ALPHA-SUBSTITUTED DERIVATIVES OF ESTRADIOL WITH WOUND-HEALING ACTIVITY | EUTICALS S.P.A. (IT) | 2010-02-11 | — | — | US | disclosed |
| EP-1910398-A1 | 17-ALPHA-SUBSTITUTED DERIVATIVES OF ESTRADIOL WITH WOUND-HEALING ACTIVITY | Euticals S.P.A. (IT) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007014711-A1 | 17-ALPHA-SUBSTITUTED DERIVATIVES OF ESTRADIOL WITH WOUND-HEALING ACTIVITY | EUTICALS S.P.A. (IT) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035796-A1 | 17-ALPHA-SUBSTITUTED DERIVATIVES OF ESTRADIOL WITH WOUND-HEALING ACTIVITY | HSD17B11, CYP19A1, ESR1 | STS 140/4885ESR1 3/4885ESR2 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.