Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30464144 | 0.76 | CYP2D6 (0.40) | KMT2ACYP2D6ALDH1A1NAMPTPOLB | |
| SCHEMBL30464130 | 0.74 | CYP2D6 (0.40) | KMT2ACYP2D6ALDH1A1NAMPTPOLB | |
| SCHEMBL12726868 | 0.73 | CYP2D6 (0.76) | KMT2ACYP2D6ALDH1A1POLBPKM | |
| SCHEMBL23903013 | 0.71 | MCOLN3 (0.60) | KMT2ACYP2D6ALDH1A1POLBPKM | |
| SCHEMBL2634000 | 0.70 | KMT2A (0.63) | KMT2AALDH1A1NAMPTPKMCYP2C19 | |
| SCHEMBL24923656 | 0.70 | KMT2A (0.76) | KMT2AALDH1A1POLBUSP2TSHR | |
| SCHEMBL23884842 | 0.69 | CYP2D6 (0.54) | CYP2D6ALDH1A1NAMPTPOLBPKM | |
| SCHEMBL12319217 | 0.68 | KMT2A (0.60) | KMT2AALDH1A1NAMPTCYP3A4KDM4E | |
| SCHEMBL22183484 | 0.68 | KMT2A (0.60) | KMT2AALDH1A1NAMPTCYP2C19KDM4E | |
| SCHEMBL12726841 | 0.68 | POLB (0.52) | KMT2ACYP2D6POLBTSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250092023-A1 | PIPERAZINE INDAZOLE GLUCOCORTICOID RECEPTOR ANTAGONISTS | CORCEPT THERAPEUTICS INCORPORATED | 2025-03-20 | — | — | US | disclosed |
| US-12098144-B2 | Piperazine indazole glucocorticoid receptor antagonists | CORCEPT THERAPEUTICS INCORPORATED (US) | 2024-09-24 | — | — | US | disclosed |
| US-20230192666-A1 | PIPERAZINE INDAZOLE GLUCOCORTICOID RECEPTOR ANTAGONISTS | CORCEPT THERAPEUTICS INCORPORATED | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250092023-A1 | PIPERAZINE INDAZOLE GLUCOCORTICOID RECEPTOR ANTAGONISTS | NR3C1, NR3C2, NR5A2 | KMT2A 3760/4885CYP2D6 397/4885ALDH1A1 1874/4885 |
| US-12098144-B2 | Piperazine indazole glucocorticoid receptor antagonists | NR3C1, NR3C2, NR5A2 | KMT2A 3693/4885CYP2D6 363/4885ALDH1A1 1750/4885 |
| US-20230192666-A1 | PIPERAZINE INDAZOLE GLUCOCORTICOID RECEPTOR ANTAGONISTS | NR3C1, NR3C2, NR5A2 | KMT2A 3760/4885CYP2D6 397/4885ALDH1A1 1874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.