Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29376321 | 0.87 | NAMPT (0.48) | MAPK1PRMT5WDR77DRD2NAMPT | |
| SCHEMBL12013723 | 0.87 | NAMPT (0.48) | MAPK1PRMT5WDR77DRD2NAMPT | |
| SCHEMBL14138611 | 0.87 | NAMPT (0.48) | MAPK1PRMT5WDR77DRD2NAMPT | |
| SCHEMBL29051832 | 0.85 | ESR2 (0.63) | NR1H2DRD2ESR2 | |
| SCHEMBL29052424 | 0.84 | NR1H2 (0.64) | NR1H2ESR2KDM1A | |
| SCHEMBL30468516 | 0.83 | ESR2 (0.47) | NR1H2DRD2ESR2ALDH1A1NOTUM | |
| SCHEMBL1791198 | 0.83 | UCHL1 (0.48) | MAPK1NR1H2PRMT5WDR77GPR119 | |
| SCHEMBL19389912 | 0.83 | DRD1 (0.53) | MAPK1NR1H2PRMT5WDR77DRD2 | |
| SCHEMBL29705902 | 0.83 | DRD1 (0.53) | MAPK1NR1H2PRMT5WDR77DRD2 | |
| SCHEMBL30429426 | 0.80 | PRMT5 (0.43) | MAPK1NR1H2PRMT5WDR77DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116332910-A | 2-aminopyrimidine derivatives as kinase inhibitors, preparation and use thereof | 江苏威凯尔医药科技有限公司 | 2023-06-27 | — | — | CN | disclosed |