Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15707763 | 1.00 | MAPT (0.44) | MAPTNPC1MAPK1HSD17B10KDM4E | |
| SCHEMBL21050144 | 0.91 | KDM4E (0.45) | MAPTNPC1MAPK1HSD17B10KDM4E | |
| SCHEMBL7809325 | 0.89 | KDM4E (0.44) | MAPTNPC1MAPK1HSD17B10KDM4E | |
| SCHEMBL15707773 | 0.85 | GPR84 (0.50) | MAPTNPC1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL29447007 | 0.85 | GPR84 (0.50) | MAPTNPC1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL5706897 | 0.82 | MAOB (0.45) | MAPTNPC1MEN1KMT2ASOS1 | |
| SCHEMBL29849556 | 0.82 | KDM4E (0.59) | MAPTNPC1KDM4EMEN1KMT2A | |
| SCHEMBL4779223 | 0.82 | KDM4E (0.59) | MAPTNPC1KDM4EMEN1KMT2A | |
| SCHEMBL30025481 | 0.82 | MAOB (0.45) | MAPTNPC1MEN1KMT2ASOS1 | |
| SCHEMBL17163963 | 0.81 | SOS1 (0.45) | MAPTNPC1MAPK1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4436976-A1 | SPIROCYCLIC MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION | Genentech, Inc. (US) | 2024-10-02 | — | — | EP | disclosed |
| CN-118510783-A | Spiro modulators of cholesterol biosynthesis and their use for promoting remyelination | 基因泰克公司 | 2024-08-16 | — | — | CN | disclosed |
| WO-2023097234-A1 | SPIROCYCLIC MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION | GENENTECH, INC. (US) | 2023-06-01 | — | — | WO | disclosed |