Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 3/20 | 0.38 |
| ▸ | MMP2 | P08253 | 3/20 | 0.38 |
| ▸ | MMP9 | P14780 | 3/20 | 0.38 |
| ▸ | MMP8 | P22894 | 3/20 | 0.38 |
| ▸ | MMP13 | P45452 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6519773 | 1.00 | CYP2C19 (0.42) | CYP2C19MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9909951 | 0.86 | ALDH1A1 (0.46) | CYP2C19MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29081418 | 0.84 | HTT (0.49) | CYP2C19MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL29477688 | 0.84 | HTT (0.49) | CYP2C19MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL29081695 | 0.82 | ALDH1A1 (0.49) | CYP2C19MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29477833 | 0.82 | ALDH1A1 (0.49) | CYP2C19MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29081282 | 0.81 | MAPT (0.41) | CYP2C19MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL914646 | 0.81 | GAA (0.54) | MAPTSMN1; SMN2ALDH1A1GLAGAA | |
| SCHEMBL857380 | 0.80 | AAK1 (0.42) | CYP2C19MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29053787 | 0.79 | GAA (0.56) | MAPTNPC1RAB9ASMN1; SMN2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4188920-A1 | PIPERIDIN-1-YL-N-PYRYDINE-3-YL-2-OXOACETAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF MTAP-DEFICIENT AND/OR MTA-ACCUMULATING CANCERS | Tango Therapeutics, Inc. (US) | 2023-06-07 | — | — | EP | disclosed |