Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 3/20 | 0.37 |
| ▸ | NOS1 | P29475 | 3/20 | 0.37 |
| ▸ | NOS2 | P35228 | 3/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25322604 | 1.00 | IDH1 (0.38) | IDH1NOS3NOS1NOS2CHRNA7 | |
| SCHEMBL30551361 | 1.00 | IDH1 (0.38) | IDH1NOS3NOS1NOS2CHRNA7 | |
| SCHEMBL24233803 | 1.00 | IDH1 (0.38) | IDH1NOS3NOS1NOS2CHRNA7 | |
| SCHEMBL30551484 | 0.81 | NOS3 (0.37) | NOS3NOS1NOS2CHRNA7CHRNB2 | |
| SCHEMBL25323877 | 0.81 | NOS3 (0.37) | NOS3NOS1NOS2CHRNA7CHRNB2 | |
| SCHEMBL25323875 | 0.81 | NOS3 (0.37) | NOS3NOS1NOS2CHRNA7CHRNB2 | |
| SCHEMBL30551289 | 0.79 | CYP1A1 (0.41) | CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL25324052 | 0.79 | CYP1A1 (0.41) | CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL25324054 | 0.79 | CYP1A1 (0.41) | CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL24366989 | 0.78 | NOS3 (0.42) | NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4188920-A1 | PIPERIDIN-1-YL-N-PYRYDINE-3-YL-2-OXOACETAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF MTAP-DEFICIENT AND/OR MTA-ACCUMULATING CANCERS | Tango Therapeutics, Inc. (US) | 2023-06-07 | — | — | EP | disclosed |