Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.72 |
| ▸ | DDB1 | Q16531 | 17/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30199279 | 0.86 | CRBN (0.67) | CRBNDDB1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL30199319 | 0.85 | CRBN (0.65) | CRBNDDB1MEN1KMT2A | |
| SCHEMBL25026932 | 0.84 | CRBN (0.77) | CRBNDDB1 | |
| SCHEMBL30472890 | 0.84 | CRBN (1.00) | CRBNDDB1MEN1USP2KMT2A | |
| SCHEMBL28984072 | 0.84 | CRBN (1.00) | CRBNDDB1MEN1USP2KMT2A | |
| SCHEMBL30472911 | 0.84 | DDB1 (0.63) | CRBNDDB1 | |
| SCHEMBL31254098 | 0.84 | CRBN (0.63) | CRBNDDB1 | |
| SCHEMBL25595586 | 0.83 | CRBN (0.76) | CRBNDDB1 | |
| SCHEMBL25578237 | 0.83 | CRBN (0.80) | CRBNDDB1 | |
| SCHEMBL25858510 | 0.82 | CRBN (0.52) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115968293-A | Cereblon binding compounds, compositions thereof, and methods of use thereof for treatment | 新基公司 | 2023-04-14 | — | — | CN | disclosed |