Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.38 |
| ▸ | CHRNG | P07510 | 1/20 | 0.38 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25213171 | 1.00 | PTGDR2 (0.43) | PTGDR2PDK2PDK4NAMPTKDM4E | |
| SCHEMBL25218839 | 0.83 | PTGDR2 (0.43) | PTGDR2ALDH1A1HCRTR2HCRTR1PGR | |
| SCHEMBL25308813 | 0.81 | POLQ (0.43) | PTGDR2PDK2PDK4KDM4EALDH1A1 | |
| SCHEMBL30526646 | 0.81 | POLQ (0.43) | PTGDR2PDK2PDK4KDM4EALDH1A1 | |
| SCHEMBL16958769 | 0.80 | CHRNA1 (0.42) | PTGDR2HCRTR2CYP11B2CHRNA1CHRNG | |
| SCHEMBL25215887 | 0.79 | PTGDR2 (0.43) | PTGDR2KDM4EALDH1A1PGRCHRNA1 | |
| SCHEMBL30474051 | 0.79 | PTGDR2 (0.43) | PTGDR2KDM4EALDH1A1PGRCHRNA1 | |
| SCHEMBL11520744 | 0.79 | CA12 (0.46) | PDK2PDK4NAMPTKDM4EALDH1A1 | |
| SCHEMBL31459981 | 0.77 | PTGDR2 (0.44) | PTGDR2PGRGRM5CHRNA1CHRNG | |
| SCHEMBL24371188 | 0.77 | HCRTR1 (0.44) | HCRTR2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4441044-A1 | SUBSTITUTED N-CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | Mission Therapeutics Limited (GB) | 2024-10-09 | — | — | EP | disclosed |
| WO-2023099561-A1 | SUBSTITUTED N-CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | MISSION THERAPEUTICS LIMITED (GB) | 2023-06-08 | — | — | WO | disclosed |