Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 14/20 | 0.62 |
| ▸ | EGLN3 | Q9H6Z9 | 9/20 | 0.62 |
| ▸ | VEGFA | P15692 | 7/20 | 0.62 |
| ▸ | FLT1 | P17948 | 7/20 | 0.62 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | TET3 | O43151 | 1/20 | 0.39 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.39 |
| ▸ | ASPH | Q12797 | 1/20 | 0.39 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.39 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.39 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.39 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.39 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.39 |
| ▸ | USP7 | Q93009 | 1/20 | 0.39 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3048516 | 0.88 | EGLN1 (0.63) | EGLN1EGLN3VEGFAFLT1PAK1 | |
| SCHEMBL1920959 | 0.82 | EGLN1 (0.65) | EGLN1EGLN3VEGFAFLT1CNR2 | |
| SCHEMBL30239261 | 0.82 | EGLN1 (0.65) | EGLN1EGLN3VEGFAFLT1CNR2 | |
| SCHEMBL3047467 | 0.82 | EGLN1 (0.50) | EGLN1EGLN3VEGFAFLT1PAK1 | |
| SCHEMBL3041651 | 0.81 | EGLN1 (0.62) | EGLN1EGLN3VEGFAFLT1CNR2 | |
| SCHEMBL3484350 | 0.79 | EGLN1 (0.58) | EGLN1EGLN3VEGFAFLT1TET3 | |
| SCHEMBL14331206 | 0.78 | EGLN1 (0.57) | EGLN1EGLN3VEGFAFLT1 | |
| SCHEMBL30287600 | 0.76 | EGLN1 (1.00) | EGLN1EGLN3VEGFAFLT1TET3 | |
| SCHEMBL1921063 | 0.76 | EGLN1 (1.00) | EGLN1EGLN3VEGFAFLT1TET3 | |
| SCHEMBL3485494 | 0.76 | PIK3CD (0.47) | EGLN1EGLN3VEGFAFLT1TET3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044005-B1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | WARNER CHILCOTT CO LLC (PR) | 2010-10-20 | — | — | EP | disclosed |
| US-7811595-B2 | such as {[5-(3-Chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid methyl ester; for controlling Peripheral Vascular Disease, Coronary Artery Disease, heart failure, ischemia, and anemia | WARNER CHILCOTT COMPANY, LLC (US) | 2010-10-12 | — | — | US | disclosed |