Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.50 |
| ▸ | EGLN3 | Q9H6Z9 | 3/20 | 0.50 |
| ▸ | VEGFA | P15692 | 2/20 | 0.50 |
| ▸ | FLT1 | P17948 | 2/20 | 0.50 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31732314 | 0.87 | EGLN1 (0.51) | EGLN1EGLN3VEGFAFLT1USP7 | |
| SCHEMBL3051475 | 0.87 | EGLN1 (0.51) | EGLN1EGLN3VEGFAFLT1USP7 | |
| SCHEMBL3047464 | 0.82 | EGLN1 (0.62) | EGLN1EGLN3VEGFAFLT1USP7 | |
| SCHEMBL1921660 | 0.81 | VEGFA (0.53) | EGLN1EGLN3VEGFAFLT1CNR2 | |
| SCHEMBL29771346 | 0.81 | VEGFA (0.53) | EGLN1EGLN3VEGFAFLT1CNR2 | |
| SCHEMBL3041653 | 0.80 | EGLN1 (0.51) | EGLN1EGLN3VEGFAFLT1USP7 | |
| SCHEMBL29772996 | 0.80 | EGLN1 (0.51) | EGLN1EGLN3VEGFAFLT1USP7 | |
| SCHEMBL3484354 | 0.78 | EGLN1 (0.46) | EGLN1EGLN3VEGFAFLT1GSK3B | |
| SCHEMBL14331207 | 0.77 | CHRNA7 (0.45) | EGLN1EGLN3VEGFAFLT1MAP4K4 | |
| SCHEMBL31348066 | 0.73 | EGLN1 (0.48) | EGLN1EGLN3VEGFAFLT1USP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044005-B1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | WARNER CHILCOTT CO LLC (PR) | 2010-10-20 | — | — | EP | disclosed |
| US-7811595-B2 | such as {[5-(3-Chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid methyl ester; for controlling Peripheral Vascular Disease, Coronary Artery Disease, heart failure, ischemia, and anemia | WARNER CHILCOTT COMPANY, LLC (US) | 2010-10-12 | — | — | US | disclosed |