Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 16/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 12/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25252861 | 1.00 | HDAC2 (0.44) | HDAC2HDAC3HDAC1MEN1NPC1 | |
| SCHEMBL31108977 | 0.88 | HDAC2 (0.50) | HDAC2HDAC3HDAC1MEN1NPC1 | |
| SCHEMBL30474714 | 0.86 | HDAC2 (0.52) | HDAC2HDAC3HDAC1MEN1NPC1 | |
| SCHEMBL25249794 | 0.86 | HDAC2 (0.52) | HDAC2HDAC3HDAC1MEN1NPC1 | |
| SCHEMBL25214555 | 0.86 | HDAC2 (0.45) | HDAC2HDAC3HDAC1 | |
| SCHEMBL30474692 | 0.86 | HDAC2 (0.45) | HDAC2HDAC3HDAC1 | |
| SCHEMBL25223186 | 0.85 | F10 (0.37) | HDAC2HDAC1MEN1NPC1RAB9A | |
| SCHEMBL25251173 | 0.83 | HDAC2 (0.60) | HDAC2HDAC3HDAC1KCNH2 | |
| SCHEMBL31108943 | 0.82 | HDAC2 (0.48) | HDAC2HDAC3HDAC1MEN1NPC1 | |
| SCHEMBL25208867 | 0.82 | HDAC2 (0.49) | HDAC2HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4441033-A1 | NOVEL HDAC INHIBITORS AND THERAPEUTIC USE THEREOF | Tango Therapeutics, Inc. (US) | 2024-10-09 | — | — | EP | disclosed |
| WO-2023102162-A1 | TGONOVEL HDAC INHIBITORS AND THERAPEUTIC USE THEREOF | TANGO THERAPEUTICS, INC. (US) | 2023-06-08 | — | — | WO | disclosed |