Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | IL1B | P01584 | 4/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3050485 | 0.92 | BDKRB1 (0.45) | BDKRB1HTR2AHTR2CHTR2BGRIN2B | |
| SCHEMBL3052388 | 0.82 | BDKRB1 (0.50) | BDKRB1HTR2AHTR2CHTR2BGRIN2B | |
| SCHEMBL3064841 | 0.82 | BDKRB1 (0.65) | BDKRB1CYP3A4CYP2C19 | |
| SCHEMBL3060336 | 0.80 | BDKRB1 (0.61) | BDKRB1CYP3A4CYP2C19 | |
| SCHEMBL3052518 | 0.76 | BDKRB1 (0.38) | BDKRB1HTR2AHTR2CHTR2BGRIN2B | |
| SCHEMBL3043088 | 0.76 | HTR2A (0.42) | BDKRB1HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL3050620 | 0.75 | BDKRB1 (0.63) | BDKRB1HTR2AHTR2CHTR2BCYP3A4 | |
| SCHEMBL13139563 | 0.75 | HTR2C (0.44) | BDKRB1HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL13178666 | 0.75 | GRIN2B (0.34) | GRIN2BIL1BP2RX7 | |
| SCHEMBL3057197 | 0.74 | BDKRB1 (0.45) | BDKRB1HTR2AHTR2CHTR2BGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222324-A1 | Substituted Indole Compounds | GRUENENTHAL GMBH (DE) | 2010-09-02 | — | — | US | claimed |
| US-8492559-B2 | Substituted indole compounds | GRUENENTHAL GMBH (DE) | 2013-07-23 | — | — | US | disclosed |
| US-8492559-B2 | Substituted indole compounds | GRUENENTHAL GMBH (DE) | 2013-07-23 | — | — | US | disclosed |
| US-8492559-B2 | Substituted indole compounds | GRUENENTHAL GMBH (DE) | 2013-07-23 | — | — | US | disclosed |
| US-20100222324-A1 | Substituted Indole Compounds | GRUENENTHAL GMBH (DE) | 2010-09-02 | — | — | US | disclosed |
| US-20100222324-A1 | Substituted Indole Compounds | GRUENENTHAL GMBH (DE) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222324-A1 | Substituted Indole Compounds | BDKRB1, BDKRB2, EDNRB | BDKRB1 1/4885HTR2A 85/4885HTR2C 221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.