Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 11/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25285748 | 1.00 | TYK2 (0.47) | TYK2AKR1C3CLK4CYP1A2CYP2C9 | |
| SCHEMBL25250500 | 0.86 | TYK2 (0.52) | TYK2AKR1C3POLBGAAALDH1A1 | |
| SCHEMBL25242771 | 0.84 | TYK2 (0.50) | TYK2AKR1C3POLBGAA | |
| SCHEMBL25243819 | 0.82 | TYK2 (0.66) | TYK2AKR1C3POLBGAA | |
| SCHEMBL25241314 | 0.81 | TYK2 (0.48) | TYK2AKR1C3POLBGAA | |
| SCHEMBL25243602 | 0.80 | TYK2 (0.49) | TYK2 | |
| SCHEMBL25246852 | 0.80 | TYK2 (0.47) | TYK2AKR1C3POLBGAAALDH1A1 | |
| SCHEMBL25292402 | 0.79 | TYK2 (0.50) | TYK2AKR1C3POLBGAA | |
| SCHEMBL25244500 | 0.78 | TYK2 (0.53) | TYK2 | |
| SCHEMBL25286983 | 0.78 | TYK2 (0.50) | TYK2AKR1C3POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | claimed |