Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 14/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 13/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25035460 | 0.85 | DDB1 (0.52) | CRBNDDB1 | |
| SCHEMBL25035459 | 0.83 | CRBN (0.44) | CRBNDDB1HSD17B10TSHRCYP3A4 | |
| SCHEMBL30136007 | 0.82 | CRBN (0.48) | CRBNDDB1HSD17B10TSHRCYP3A4 | |
| SCHEMBL25825240 | 0.81 | CRBN (0.41) | CRBNDDB1 | |
| SCHEMBL25192137 | 0.81 | KDM4E (0.51) | CRBNDDB1HSD17B10CYP2C19 | |
| SCHEMBL25188466 | 0.81 | KDM4E (0.51) | CRBNDDB1HSD17B10CYP2C19 | |
| SCHEMBL31487437 | 0.79 | DDB1 (0.51) | CRBNDDB1HSD17B10CYP3A4ALDH1A1 | |
| SCHEMBL25209668 | 0.78 | KDM4E (0.46) | CRBNDDB1HSD17B10TSHRCYP2C19 | |
| SCHEMBL25188969 | 0.76 | CRBN (0.38) | CRBNDDB1HSD17B10ALDH1A1CYP2C19 | |
| SCHEMBL24671266 | 0.76 | CRBN (0.44) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116322700-B | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2024-08-20 | — | — | CN | disclosed |
| CN-116322700-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2023-06-23 | — | — | CN | disclosed |