Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 9/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25035460 | 0.84 | DDB1 (0.52) | CRBNDDB1GPR119 | |
| SCHEMBL30475447 | 0.82 | CRBN (0.41) | CRBNHSD17B10TSHRKMT2ADDB1 | |
| SCHEMBL30135914 | 0.81 | CRBN (0.48) | CRBNHSD17B10TSHRNPC1POLB | |
| SCHEMBL30135908 | 0.79 | HSD17B10 (0.42) | HSD17B10TSHRPOLBKMT2AGPR119 | |
| SCHEMBL30441826 | 0.79 | CRBN (0.55) | CRBNNPC1POLBKMT2ADDB1 | |
| SCHEMBL30135777 | 0.76 | CRBN (0.48) | CRBNHSD17B10TSHRNPC1POLB | |
| SCHEMBL30135848 | 0.75 | LMNA (0.39) | HSD17B10TSHRPOLBKMT2AGPR119 | |
| SCHEMBL25035459 | 0.74 | CRBN (0.44) | CRBNHSD17B10TSHRPOLBDDB1 | |
| SCHEMBL25825240 | 0.73 | CRBN (0.41) | CRBNPOLBDDB1 | |
| SCHEMBL30135799 | 0.72 | CRBN (0.51) | CRBNNPC1DDB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157849-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | Uppthera, Inc. (KR) | 2023-04-05 | — | — | EP | disclosed |
| WO-2023017446-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023018238-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |