Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23619586 | 0.85 | CA12 (0.46) | ABCG2CA12CA1CA2CA9 | |
| SCHEMBL3044158 | 0.83 | ABCG2 (0.44) | ABCG2SLC7A5CA12CA1CA2 | |
| SCHEMBL3044156 | 0.83 | ABCG2 (0.44) | ABCG2SLC7A5CA12CA1CA2 | |
| SCHEMBL5090323 | 0.82 | SLC7A5 (0.55) | ABCG2SLC7A5STAT3RAB9AALDH1A1 | |
| SCHEMBL30478996 | 0.82 | SLC7A5 (0.55) | ABCG2SLC7A5STAT3RAB9AALDH1A1 | |
| SCHEMBL8371979 | 0.81 | CYP17A1 (0.47) | CA12CA1CA9RAB9ANPC1 | |
| SCHEMBL8373344 | 0.81 | CYP17A1 (0.47) | CA12CA1CA9RAB9ANPC1 | |
| SCHEMBL6706829 | 0.78 | SMN1; SMN2 (0.56) | CA12CA1CA2CA9CA14 | |
| SCHEMBL6706826 | 0.78 | SMN1; SMN2 (0.56) | CA12CA1CA2CA9CA14 | |
| SCHEMBL350279 | 0.78 | TP53 (0.48) | CA12CA1CA2CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116261458-B | PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2024-05-24 | — | — | CN | disclosed |
| CN-116261458-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2023-06-13 | — | — | CN | disclosed |