Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.38 |
| ▸ | ITGAL | P20701 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25940006 | 1.00 | ITGB2 (0.38) | ITGB2ICAM1ITGALLRRK2GRM5 | |
| SCHEMBL25935357 | 0.92 | ITGB2 (0.39) | ITGB2ICAM1ITGALLRRK2EHMT2 | |
| SCHEMBL25034764 | 0.89 | GRM5 (0.38) | LRRK2GRM5HRH4FFAR4 | |
| SCHEMBL30475431 | 0.89 | GRM5 (0.38) | LRRK2GRM5HRH4FFAR4 | |
| SCHEMBL29013203 | 0.89 | NEK2 (0.43) | ITGB2ICAM1ITGALGRM5GPR84 | |
| SCHEMBL25031334 | 0.87 | FFAR4 (0.47) | LRRK2GRM5FFAR4 | |
| SCHEMBL30479023 | 0.85 | HPGD (0.49) | MAPTMAPK1 | |
| SCHEMBL25940005 | 0.85 | HPGD (0.49) | MAPTMAPK1 | |
| SCHEMBL23983537 | 0.84 | LRRK2 (0.44) | LRRK2GRM5MAPK1HRH4 | |
| SCHEMBL24670613 | 0.84 | LRRK2 (0.46) | LRRK2EHMT2MAPTMAPK1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116261458-B | PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2024-05-24 | — | — | CN | disclosed |
| CN-116261458-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2023-06-13 | — | — | CN | disclosed |