Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 11/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 9/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25334284 | 1.00 | ESR1 (0.40) | ESR1ESR2KDM4ENPSR1POLB | |
| SCHEMBL25952570 | 0.91 | ESR1 (0.41) | ESR1ESR2KDM4ENPSR1POLB | |
| SCHEMBL30479245 | 0.79 | ESR1 (0.47) | ESR1ESR2 | |
| SCHEMBL25331989 | 0.79 | ESR1 (0.47) | ESR1ESR2 | |
| SCHEMBL21947673 | 0.75 | ESR1 (0.42) | ESR1ESR2KDM4EKMT2A | |
| SCHEMBL21947664 | 0.71 | ESR1 (0.67) | ESR1 | |
| SCHEMBL25952545 | 0.71 | ESR1 (0.47) | ESR1ESR2 | |
| SCHEMBL25967134 | 0.69 | PDE4A (0.34) | ESR1ESR2KMT2A | |
| SCHEMBL30604773 | 0.69 | ESR1 (0.49) | ESR1ESR2 | |
| SCHEMBL25953323 | 0.69 | ESR1 (0.49) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4472982-A1 | PROCESSES FOR THE PREPARATION OF SELECTIVE ESTROGEN RECEPTOR DEGRADERS | Eli Lilly and Company (US) | 2024-12-11 | — | — | EP | disclosed |
| CN-118647619-A | Process for preparing selective estrogen receptor degrading agent | 伊莱利利公司 | 2024-09-13 | — | — | CN | disclosed |
| WO-2023150056-A1 | PROCESSES FOR THE PREPARATION OF SELECTIVE ESTROGEN RECEPTOR DEGRADERS | ELI LILLY AND COMPANY (US) | 2023-08-10 | — | — | WO | disclosed |