Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | MELK | Q14680 | 4/20 | 0.31 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.30 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25953862 | 0.85 | PDE4A (0.33) | PDE4APDE4BPDE4CPDE4DESR1 | |
| SCHEMBL25967111 | 0.84 | CYP8B1 (0.38) | CSF1R | |
| SCHEMBL21947673 | 0.83 | ESR1 (0.42) | PDE4APDE4BPDE4CPDE4DESR1 | |
| SCHEMBL25332384 | 0.80 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DESR1 | |
| SCHEMBL30479252 | 0.80 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DESR1 | |
| SCHEMBL25967153 | 0.75 | ESR1 (0.40) | ESR1 | |
| SCHEMBL20480289 | 0.70 | ESR2 (0.41) | ESR1ESR2RETMEN1CYP3A4 | |
| SCHEMBL30479233 | 0.69 | ESR1 (0.40) | ESR1ESR2KMT2A | |
| SCHEMBL25334284 | 0.69 | ESR1 (0.40) | ESR1ESR2KMT2A | |
| SCHEMBL25952570 | 0.69 | ESR1 (0.41) | ESR1ESR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023150056-A1 | PROCESSES FOR THE PREPARATION OF SELECTIVE ESTROGEN RECEPTOR DEGRADERS | ELI LILLY AND COMPANY (US) | 2023-08-10 | — | — | WO | disclosed |