Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 12/20 | 0.76 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.64 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.64 |
| ▸ | GSK3B | P49841 | 1/20 | 0.64 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18662657 | 0.86 | CLK1 (0.57) | CLK1CDK5CDK5R1GSK3BDYRK1A | |
| SCHEMBL29431253 | 0.86 | CLK1 (0.57) | CLK1CDK5CDK5R1GSK3BDYRK1A | |
| SCHEMBL29466936 | 0.77 | JAK1 (0.62) | JAK1JAK2 | |
| SCHEMBL26987746 | 0.76 | CLK1 (0.46) | CLK1CDK5CDK5R1GSK3BDYRK1A | |
| SCHEMBL30756821 | 0.76 | CLK1 (0.46) | CLK1CDK5CDK5R1GSK3BDYRK1A | |
| SCHEMBL23130605 | 0.74 | CLK1 (0.59) | CLK1CDK5CDK5R1GSK3BDYRK1A | |
| SCHEMBL30018377 | 0.74 | CLK1 (0.59) | CLK1CDK5CDK5R1GSK3BDYRK1A | |
| SCHEMBL20400706 | 0.74 | JAK2 (0.62) | JAK1JAK2 | |
| SCHEMBL24474748 | 0.74 | JAK1 (0.67) | JAK1JAK2 | |
| SCHEMBL16075920 | 0.74 | CLK1 (0.71) | CLK1CDK5CDK5R1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219482-A1 | COMPOUNDS AND METHODS FOR INHIBITING JAK | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2023-08-02 | — | — | EP | disclosed |