Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 15/20 | 0.44 |
| ▸ | JAK2 | O60674 | 13/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26987746 | 1.00 | CLK1 (0.46) | CLK1JAK1JAK2DYRK1AGSK3B | |
| SCHEMBL26987459 | 0.86 | JAK1 (0.39) | CLK1JAK1JAK2KCNH2 | |
| SCHEMBL30757260 | 0.86 | JAK1 (0.39) | CLK1JAK1JAK2KCNH2 | |
| SCHEMBL30757032 | 0.85 | JAK1 (0.40) | JAK1JAK2KCNH2 | |
| SCHEMBL26987611 | 0.85 | JAK1 (0.40) | JAK1JAK2KCNH2 | |
| SCHEMBL26993838 | 0.84 | JAK1 (0.47) | JAK1JAK2KCNH2 | |
| SCHEMBL30756723 | 0.84 | JAK1 (0.46) | CLK1JAK1JAK2CDK5CDK5R1 | |
| SCHEMBL26987136 | 0.84 | JAK1 (0.46) | CLK1JAK1JAK2CDK5CDK5R1 | |
| SCHEMBL29466936 | 0.83 | JAK1 (0.62) | JAK1JAK2 | |
| SCHEMBL30757036 | 0.83 | JAK1 (0.37) | JAK1JAK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4551570-A1 | NOVEL COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | Dong-A ST Co., Ltd. (KR) | 2025-05-14 | — | — | EP | disclosed |
| CN-119403798-A | Novel compounds as GCN2 inhibitors, pharmaceutical compositions and uses thereof | 东亚ST 株式会社 | 2025-02-07 | — | — | CN | disclosed |
| WO-2024009215-A1 | NOVEL COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | DONG-A ST CO., LTD. (KR) | 2024-01-11 | — | — | WO | disclosed |