Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.32 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.32 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1550437 | 1.00 | HTT (0.40) | HTTKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL1550435 | 1.00 | HTT (0.40) | HTTKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL2982328 | 0.87 | HTT (0.40) | HTTKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL13773302 | 0.87 | HTT (0.40) | HTTKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL3828343 | 0.87 | HTT (0.40) | HTTKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL6478807 | 0.75 | TSHR (0.42) | HTTKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL6478809 | 0.75 | TSHR (0.42) | HTTKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL13415701 | 0.75 | HTT (0.36) | HTTKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL24212085 | 0.73 | HTT (0.46) | HTTKMT2AMEN1ALDH1A1SLC22A12 | |
| SCHEMBL29950969 | 0.73 | HTT (0.46) | HTTKMT2AMEN1ALDH1A1SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4444421-A2 | HETEROCYCLIC COMPOUNDS AS DYRK1A INHIBITORS | Prothena Biosciences Limited (IE) | 2024-10-16 | — | — | EP | disclosed |
| WO-2023107714-A2 | METHODS FOR TREATING NEUROLOGICAL DISORDERS | PROTHENA BIOSCIENCES LIMITED (IE) | 2023-06-15 | — | — | WO | disclosed |