Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.37 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PLEC | Q15149 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25375578 | 1.00 | ALDH1A1 (0.55) | ALDH1A1KDM4EMAPTGAATSHR | |
| Formaldehyde SCHEMBL25376880 | 0.94 | MAPT (0.50) | ALDH1A1KDM4EMAPTGAATSHR | |
| SCHEMBL148781 | 0.80 | ALDH1A1 (0.55) | ALDH1A1KDM4EMAPTGAATSHR | |
| SCHEMBL819145 | 0.79 | TSHR (0.59) | ALDH1A1KDM4EMAPTGAATSHR | |
| SCHEMBL9666898 | 0.79 | MAPT (0.40) | ALDH1A1KDM4EMAPTGAATSHR | |
| SCHEMBL10330189 | 0.79 | ALDH1A1 (0.55) | ALDH1A1KDM4EMAPTGAATSHR | |
| Iodide SCHEMBL31276096 | 0.78 | ALDH1A1 (0.53) | ALDH1A1KDM4EMAPTGAATSHR | |
| SCHEMBL14562499 | 0.78 | MAPT (0.53) | ALDH1A1KDM4EMAPTGAATSHR | |
| SCHEMBL29646332 | 0.78 | MAPT (0.53) | ALDH1A1KDM4EMAPTGAATSHR | |
| SCHEMBL5642052 | 0.77 | MAPT (0.55) | ALDH1A1KDM4EMAPTGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4469438-A1 | COMPOUNDS AND METHODS OF USE | Tango Therapeutics, Inc. (US) | 2024-12-04 | — | — | EP | disclosed |
| WO-2023146987-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |