Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 5/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3048360 | 1.00 | CYP3A4 (0.39) | CYP3A4CYP2C19HTR1APPARGPPARA | |
| SCHEMBL3055732 | 0.92 | TACR1 (0.44) | HTR1APPARGPPARATACR1HCRTR1 | |
| SCHEMBL3046296 | 0.92 | TACR1 (0.44) | HTR1APPARGPPARATACR1HCRTR1 | |
| SCHEMBL3052727 | 0.90 | NR1I2 (0.39) | CYP3A4CYP2C19HTR1APPARGPPARA | |
| SCHEMBL3057173 | 0.90 | NR1I2 (0.39) | CYP3A4CYP2C19HTR1APPARGPPARA | |
| SCHEMBL3048345 | 0.87 | HCRTR1 (0.41) | HTR1APPARGPPARAHCRTR1HCRTR2 | |
| SCHEMBL3048364 | 0.87 | HCRTR1 (0.41) | HTR1APPARGPPARAHCRTR1HCRTR2 | |
| SCHEMBL3062715 | 0.87 | F2 (0.41) | HTR1APPARGPPARATACR1HCRTR1 | |
| SCHEMBL3062581 | 0.87 | F2 (0.41) | HTR1APPARGPPARATACR1HCRTR1 | |
| SCHEMBL3049767 | 0.86 | HCRTR1 (0.47) | HTR1AHCRTR1HCRTR2KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222396-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222396-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | CYP11B2, CYP11B1, BBC3 | CYP3A4 101/4885CYP2C19 357/4885HTR1A 1265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.