Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3430059 | 0.76 | PDE4B (0.33) | PDE4BNR1H2NR1H3PTPN1 | |
| SCHEMBL30484622 | 0.76 | CHRM2 (0.36) | PDE4BNR1H2NR1H3PTPN1 | |
| SCHEMBL882907 | 0.76 | CHRM2 (0.36) | PDE4BNR1H2NR1H3PTPN1 | |
| SCHEMBL8288617 | 0.76 | CHRM2 (0.36) | PDE4BNR1H2NR1H3PTPN1 | |
| SCHEMBL875863 | 0.76 | CHRM2 (0.36) | PDE4BNR1H2NR1H3PTPN1 | |
| SCHEMBL16749436 | 0.75 | NR1H2 (0.35) | PDE4BNR1H2NR1H3PTPN1 | |
| SCHEMBL21366881 | 0.67 | PDE4B (0.32) | PDE4BNR1H2NR1H3PTPN1 | |
| SCHEMBL19434629 | 0.67 | NR1H2 (0.48) | PDE4BNR1H2PTPN1 | |
| SCHEMBL3431313 | 0.67 | HSD17B10 (0.39) | NR1H2 | |
| SCHEMBL883199 | 0.67 | NR1H2 (0.35) | PDE4BNR1H2NR1H3PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250223259-A1 | PROTEASE INHIBITORS FOR TREATING OR PREVENTING CORONAVIRUS INFECTION | MERCK SHARP & DOHME LLC (US) | 2025-07-10 | — | — | US | disclosed |
| EP-4460508-A1 | PROTEASE INHIBITORS FOR TREATING OR PREVENTING CORONAVIRUS INFECTION | Merck Sharp & Dohme LLC (US) | 2024-11-13 | — | — | EP | disclosed |
| WO-2023133174-A1 | PROTEASE INHIBITORS FOR TREATING OR PREVENTING CORONAVIRUS INFECTION | MERCK SHARP & DOHME LLC (US) | 2023-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250223259-A1 | PROTEASE INHIBITORS FOR TREATING OR PREVENTING CORONAVIRUS INFECTION | ACE2, PRSS2, PRSS1 | PDE4B 2770/4885NR1H2 1473/4885NR1H3 1572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.