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PRSS2

Trypsin-2 · P07478 · PRSS2 on Sugi Atlas →

140,423 patent compounds predicted against PRSS2, 91,319 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL29945 SCHEMBL29945 0.48 7/20
Camostat Camostat (SCHEMBL125270) 1.00 5/20
SCHEMBL48986 SCHEMBL48986 0.57 5/20
Benzamidine Benzamidine (SCHEMBL61379) 0.94 4/20
SCHEMBL24140 SCHEMBL24140 0.50 4/20
SCHEMBL123126 SCHEMBL123126 0.48 4/20
SCHEMBL23932 SCHEMBL23932 0.48 4/20
SCHEMBL126341 SCHEMBL126341 0.46 4/20
SCHEMBL73684 SCHEMBL73684 0.44 4/20
Potassium Ion Potassium Ion (SCHEMBL123125) 0.43 4/20
Potassium Ion Potassium Ion (SCHEMBL126340) 0.41 4/20
SCHEMBL107649 SCHEMBL107649 0.71 3/20
SCHEMBL49594 SCHEMBL49594 0.67 3/20
SCHEMBL42643 SCHEMBL42643 0.64 3/20
SCHEMBL42659 SCHEMBL42659 0.64 3/20
Methyl Orange Methyl Orange (SCHEMBL19662) 0.62 3/20
SCHEMBL108421 SCHEMBL108421 0.62 3/20
SCHEMBL67270 SCHEMBL67270 0.62 3/20
SCHEMBL33350 SCHEMBL33350 0.61 3/20
SCHEMBL33351 SCHEMBL33351 0.61 3/20

Clinical trials — most relevant to PRSS2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Prevention of Infection and Incidence of COVID-19 in Medical Personnel Assisting Patients With New Coronavirus Disease PHASE4COMPLETED
Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized) PHASE3UNKNOWN
Clinical Trial With Aprotinin in the Acute Respiratory Distress Syndrome Treatment PHASE3NOT_YET_RECRUITING
Proxalutamide Treatment for COVID-19 Patients in Intensive Care Unit PHASE3WITHDRAWN
Proxalutamide Treatment for COVID-19 Female Outpatients PHASE3WITHDRAWN
Use of Ultrase® MT12 in Young Cystic Fibrosis Children (CF) PHASE3COMPLETED
Androgen Deprivation Therapy and Vorinostat Followed by Radical Prostatectomy in Treating Patients With Localized Prostate Cancer PHASE2COMPLETED
A Pilot Study of Use of Calcium Channel Blocker to Decrease Inflammation and Pain in Hereditary Pancreatitis PHASE1/PHASE2COMPLETED
Combination Therapy With Isotretinoin and Tamoxifen Expected to Provide Complete Protection Against Severe Acute Respiratory Syndrome Coronavirus PHASE2UNKNOWN
Tranexamic Acid (TXA) and Corona Virus 2019 (COVID19) in Inpatients PHASE2WITHDRAWN
NestaCell® Mesenchymal Stem Cell to Treat Patients With Severe COVID-19 Pneumonia PHASE2COMPLETED
Trial of Alpha One Antitrypsin Inhalation in Treating Patient With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) EARLY_PHASE1UNKNOWN
French National Cohort of Patients With PRSS1 Mutations nanRECRUITING
Acute Pancreatitis Targets (APT) Study nanCOMPLETED
Angiotensin-converting Enzyme 2 (ACE2) Expression in Tonsils and Adenoids nanWITHDRAWN
Osteopathic Manipulative Therapy Effects on Post-Acute Sequelae of COVID-19 (PASC) or Long COVID nanRECRUITING
Genetic Determinism of Epithelial Barrier Defects in Irritable Bowel Syndrome nanWITHDRAWN
ACE2 Gender Differences in Stroke With COVID-19 nanCOMPLETED
Periodontal Health in Post COVID-19 Patients nanUNKNOWN
Nasal Epithelial Genetic and Single Cell RNA COVID-19 Study nanWITHDRAWN
Effect of Mepolizumab on Severe Eosinophilic Asthma nanUNKNOWN
Association Between Periodontitis and Coronavirus Disease (COVID-19) nanCOMPLETED
MIcrovascular Dysfunction in CRitically Ill cOVID-19 Patients nanUNKNOWN
In-vitro Diagnostic Test to Predict COVID-19 Mortality and Disease Severity nanWITHDRAWN
Cardiac Injury in COVID-19: a Pathology Study nanUNKNOWN
Impact of the Genetic Polymorphism on COVID-19 in Egypt nanUNKNOWN
Integrated Proteomic HPLC-ESI-MS Analysis of Salivary Peptides of Preterm Newborns: a Pilot Study nanCOMPLETED
HSD3B1 Gene Polymorphisms With Outcomes in SARS-CoV-2 Infected Patients nanCOMPLETED
Anti-Androgen Treatment for COVID-19 nanCOMPLETED
Respiratory Cathepsins, Proteases Inhibitors and Glycosaminoglycans (GAG) in Mucopolysaccharidosis nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a PRSS2 binder may also engage these)

ProteinNameSimilarity
PRSS1 Serine protease 1 0.995 landscape →
P07146 — 0.990 P07146 →
Q8NHM4 — 0.989 Q8NHM4 →
P35031 — 0.986 P35031 →
Q9QUK9 — 0.986 Q9QUK9 →
P00763 — 0.984 P00763 →
Q29463 — 0.983 Q29463 →
P51588 — 0.982 P51588 →
P70059 — 0.982 P70059 →
Q90629 — 0.981 Q90629 →
Q9R0T7 — 0.981 Q9R0T7 →
A1KXI1 — 0.981 A1KXI1 →
P00765 — 0.980 P00765 →
P00762 — 0.980 P00762 →
P80646 — 0.979 P80646 →
P29786 — 0.979 P29786 →
P16049 — 0.978 P16049 →
Q91041 — 0.978 Q91041 →
P49275 — 0.977 P49275 →
P08426 — 0.977 P08426 →
P35037 — 0.977 P35037 →
P35588 — 0.976 P35588 →
P06872 — 0.976 P06872 →
P07338 — 0.976 P07338 →
P06871 — 0.976 P06871 →
P35005 — 0.975 P35005 →
CTRB1 Chymotrypsinogen B 0.975 landscape →
O97399 — 0.974 O97399 →
P00766 — 0.973 P00766 →
Q00871 — 0.973 Q00871 →