Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 8/20 | 0.37 |
| ▸ | BTK | Q06187 | 3/20 | 0.36 |
| ▸ | CDK7 | P50613 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK14 | O94921 | 1/20 | 0.35 |
| ▸ | CCNY | Q8ND76 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | CCNK | O75909 | 2/20 | 0.33 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | TXK | P42681 | 1/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20416389 | 0.87 | CDK2 (0.45) | JAK3BTKCDK7CDK9CDK2 | |
| SCHEMBL18909668 | 0.79 | CHRNB2 (0.38) | JAK3BTKFGFR2FGFR1EGFR | |
| SCHEMBL25977011 | 0.78 | JAK3 (0.37) | JAK3BTKCDK7CDK9CDK14 | |
| SCHEMBL22631089 | 0.78 | JAK3 (0.37) | JAK3BTKFGFR2FGFR1CCNK | |
| SCHEMBL31062632 | 0.77 | CHRNB2 (0.35) | JAK3 | |
| SCHEMBL18909558 | 0.76 | JAK3 (0.41) | JAK3BTKFGFR2FGFR1EGFR | |
| SCHEMBL20839697 | 0.76 | JAK3 (0.41) | JAK3BTKCDK7CDK9CDK2 | |
| SCHEMBL20839695 | 0.76 | JAK3 (0.41) | JAK3BTKCDK7CDK9CDK2 | |
| SCHEMBL29774313 | 0.75 | SMN1; SMN2 (0.46) | JAK3BTKCDK7CDK9FGFR2 | |
| SCHEMBL20892791 | 0.75 | JAK3 (0.36) | JAK3BTKCDK7CDK9FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4419207-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | Artios Pharma Limited (GB) | 2024-08-28 | — | — | EP | disclosed |
| WO-2023067354-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | ARTIOS PHARMA LIMITED (GB) | 2023-04-27 | — | — | WO | disclosed |