Sugi Predict

Sugi Predict / Compounds / SCHEMBL30485705

SCHEMBL30485705

SCHEMBL30485705

CCn1c(=O)c2c(C3(C#N)COC3)c(S(N)(=O)=O)ccc2n(CC)c1=O

nearest known ligand 0.40

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ PARG Q86W56 7/20 0.40
▸ ALDH1A1 P00352 4/20 0.39
▸ KDM4E B2RXH2 2/20 0.32
▸ GAA P10253 1/20 0.32
▸ MAPT P10636 1/20 0.32
▸ GFER P55789 1/20 0.32
▸ USP2 O75604 1/20 0.31
▸ TSHR P16473 1/20 0.30
▸ KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28536670 0.66 PARG (0.54) PARG
SCHEMBL30485669 0.64 PARG (0.83) PARGTSHRKMT2A
SCHEMBL25364507 0.64 PARG (0.83) PARGTSHRKMT2A
SCHEMBL26022966 0.60 PARG (0.54) PARGTSHRKMT2A
SCHEMBL25352575 0.58 PARG (0.81) PARGTSHRKMT2A
SCHEMBL25365092 0.58 PARG (0.69) PARGTSHRKMT2A
SCHEMBL25365347 0.58 PARG (0.69) PARGTSHRKMT2A
SCHEMBL30485576 0.58 PARG (0.69) PARGTSHRKMT2A
SCHEMBL25365270 0.58 PARG (0.69) PARGTSHRKMT2A
SCHEMBL25364347 0.58 PARG (0.69) PARGTSHRKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4479387-A1 INHIBITORS OF PARG ARase Therapeutics Inc. (US) 2024-12-25 — — EP disclosed
WO-2023154913-A1 INHIBITORS OF PARG ARASE THERAPEUTICS INC. (US) 2023-08-17 — — WO disclosed