Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | NPC1 | O15118 | 2/20 | 0.69 |
| ▸ | RAB9A | P51151 | 2/20 | 0.69 |
| ▸ | HPGD | P15428 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | CASP3 | P42574 | 4/20 | 0.63 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | AHR | P35869 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | CETP | P11597 | 7/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24454894 | 1.00 | KDM4E (0.69) | KDM4EMAPTNPC1RAB9AHPGD | |
| SCHEMBL24454897 | 1.00 | KDM4E (0.69) | KDM4EMAPTNPC1RAB9AHPGD | |
| SCHEMBL29686421 | 1.00 | KDM4E (0.69) | KDM4EMAPTNPC1RAB9AHPGD | |
| SCHEMBL24454970 | 1.00 | KDM4E (0.69) | KDM4EMAPTNPC1RAB9AHPGD | |
| SCHEMBL30486928 | 1.00 | KDM4E (0.69) | KDM4EMAPTNPC1RAB9AHPGD | |
| SCHEMBL24454920 | 0.92 | NPC1 (0.58) | KDM4EMAPTNPC1RAB9AHPGD | |
| SCHEMBL2243986 | 0.83 | CASP3 (0.70) | KDM4EMAPTNPC1RAB9AHPGD | |
| SCHEMBL24454876 | 0.82 | MAPK10 (0.51) | KDM4EMAPTNPC1RAB9AHPGD | |
| SCHEMBL2248739 | 0.81 | MAPT (0.65) | KDM4EMAPTNPC1RAB9AHPGD | |
| SCHEMBL2245386 | 0.81 | MAPT (0.65) | KDM4EMAPTNPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4247800-B1 | N-SUBSTITUTED 4-(1,3-ARYLOXAZOLO-2-YL)PHENYL COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | HOFFMANN LA ROCHE (CH) | 2024-11-13 | — | — | EP | claimed |
| CN-116438166-A | N-substituted 4- (1, 3-aryloxazol-2-yl) phenyl compounds for the treatment and prevention of hepatitis b virus infection | 豪夫迈·罗氏有限公司 | 2023-07-14 | — | — | CN | claimed |
| CN-116438166-A | N-substituted 4- (1, 3-aryloxazol-2-yl) phenyl compounds for the treatment and prevention of hepatitis b virus infection | 豪夫迈·罗氏有限公司 | 2023-07-14 | — | — | CN | disclosed |