Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | OXTR | P30559 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.31 |
| ▸ | ITGAV | P06756 | 3/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.30 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.30 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.30 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.30 |
| ▸ | NNMT | P40261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20158099 | 1.00 | CHRNA7 (0.37) | CHRNA7GPR119LMNAMMP13MEN1 | |
| SCHEMBL21317544 | 0.91 | CHRNA7 (0.36) | CHRNA7GPR119MMP13OXTRITGB3 | |
| SCHEMBL20158102 | 0.87 | CHRNA7 (0.39) | CHRNA7GPR119MMP13ITGB3ITGAV | |
| SCHEMBL20158097 | 0.87 | CHRNA7 (0.39) | CHRNA7GPR119LMNAMMP13OXTR | |
| SCHEMBL20139821 | 0.87 | CHRNA7 (0.39) | CHRNA7ITGB3ITGAVFFAR1ITGB1 | |
| SCHEMBL20158100 | 0.86 | CHRNA7 (0.39) | CHRNA7GPR119LMNAMMP13MEN1 | |
| SCHEMBL20158106 | 0.85 | CHRNA7 (0.36) | CHRNA7GPR119MMP13OXTRITGB3 | |
| SCHEMBL20158098 | 0.83 | CHRNA7 (0.35) | CHRNA7GPR119OXTRITGB3ITGAV | |
| SCHEMBL30487531 | 0.81 | CHRNA7 (0.39) | CHRNA7GPR119MMP13MEN1KMT2A | |
| SCHEMBL20158105 | 0.81 | CHRNA7 (0.39) | CHRNA7GPR119MMP13MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11639353-B2 | Cyclobutanes- and azetidine-containing mono and spirocyclic compounds as αV integrin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11639353-B2 | Cyclobutanes- and azetidine-containing mono and spirocyclic compounds as αV integrin inhibitors | ITGB1, ITGB2, ITGA1 | CHRNA7 862/4885GPR119 243/4885LMNA 2992/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.