SCHEMBL3049378

SCHEMBL3049378

COC(=O)c1cc(C(=O)O)cc(-c2ccccc2)c1

nearest known ligand 0.59

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 4/20 0.59
TSHR P16473 1/20 0.57
EGFR P00533 2/20 0.54
KMO O15229 1/20 0.52
FABP1 P07148 1/20 0.50
P2RY14 Q15391 1/20 0.50
GABRG2 P18507 1/20 0.48
GABRB3 P28472 1/20 0.48
GABRA5 P31644 1/20 0.48
GABRA3 P34903 1/20 0.48
CA12 O43570 1/20 0.48
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
CA9 Q16790 1/20 0.48
GAA P10253 1/20 0.47
PTPN1 P18031 1/20 0.47
NR4A2 P43354 1/20 0.47
LMNA P02545 1/20 0.46
HPGD P15428 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7823750 0.94 TSHR (0.63) DHODHTSHREGFRGABRG2GABRB3
SCHEMBL4257678 0.91 TSHR (0.63) TSHREGFRKMOGABRG2GABRB3
SCHEMBL15008457 0.87 RXRA (0.61) TSHREGFRCA12CA1CA2
SCHEMBL27878777 0.87 TSHR (0.68) TSHREGFRKMOGABRG2GABRB3
Benzene SCHEMBL18691853 0.87 TSHR (0.60) TSHREGFRGABRG2GABRB3GABRA5
SCHEMBL1495508 0.86 DHODH (0.57) DHODHTSHREGFRFABP1P2RY14
SCHEMBL184501 0.85 KDM4E (0.55) DHODHTSHREGFRLMNA
SCHEMBL9121827 0.84 CA12 (0.60) TSHRCA12CA1CA2CA9
SCHEMBL27736451 0.84 DHODH (0.77) DHODHTSHREGFRKMOFABP1
SCHEMBL1768904 0.84 DHODH (0.77) DHODHTSHREGFRKMOFABP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113527217-B Diketopiperazine compound and application thereof 上海惠永药物研究有限公司 2025-05-23 CN disclosed
CN-113527216-B Preparation method of diketopiperazine compound, intermediate thereof and preparation method thereof 上海惠永药物研究有限公司 2025-03-21 CN disclosed
CN-113527216-A Preparation method of diketopiperazine compound, intermediate and preparation method thereof 上海惠永药物研究有限公司 2021-10-22 CN disclosed
CN-113527217-A Diketopiperazine compound and application thereof 上海惠永药物研究有限公司 2021-10-22 CN disclosed
CN-102958912-B Benzohydrol derivatives, a preparation process and pharmaceutical use thereof SHANGHAI HENGRUI PHARM CO LTD 2015-01-14 CN disclosed
US-8536198-B2 Piperidine derivatives as modulators of chemokine receptor activity BRISTOL-MYERS SQUIBB COMPANY (US) 2013-09-17 US disclosed
US-8536198-B2 Piperidine derivatives as modulators of chemokine receptor activity BRISTOL-MYERS SQUIBB COMPANY (US) 2013-09-17 US disclosed
US-8536198-B2 Piperidine derivatives as modulators of chemokine receptor activity BRISTOL-MYERS SQUIBB COMPANY (US) 2013-09-17 US disclosed
EP-2173714-B9 PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL MYERS SQUIBB CO (US) 2013-04-10 EP disclosed
EP-2173714-B9 PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL MYERS SQUIBB CO (US) 2013-04-10 EP disclosed
CN-101808990-A Piperidine derivatives as modulators of chemokine receptor activity BRISTOL MYERS SQUIBB CO 2010-08-18 CN disclosed
EP-2173714-A1 PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Bristol-Myers Squibb Company (US) 2010-04-14 EP disclosed
WO-2009015166-A1 PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB COMPANY (US) 2009-01-29 WO disclosed
WO-2009015166-A1 PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB COMPANY (US) 2009-01-29 WO disclosed
CN-1080257-C Guanidine derivatives as inhibitors of Na+/H+ exchange in cells FUJISAWA PHARMACEUTICAL CO (JP) 2002-03-06 CN disclosed
EP-0699185-B1 GUANIDINE DERIVATIVES AS INHIBITORS OF Na+ /H+ EXCHANGE IN CELLS FUJISAWA PHARMACEUTICAL CO (JP) 2001-09-05 EP disclosed
US-5824691-A CARDIOVASCULAR, CEREBROVASCULAR, RENAL DISEASES; SHOCK, ARTERIOSCLEROSIS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-10-20 US disclosed
CN-1123545-A Guanidine derivatives as inhibitors of Na+/H+ exchange in cells FUJISAWA PHARMACEUTICAL CO (JP) 1996-05-29 CN disclosed
EP-0699185-A1 GUANIDINE DERIVATIVES AS INHIBITORS OF Na+ /H+ EXCHANGE IN CELLS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-03-06 EP disclosed
WO-1994026709-A1 GUANIDINE DERIVATIVES AS INHIBITORS OF Na+/H+ EXCHANGE IN CELLS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-11-24 WO disclosed