Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK2 | Q92630 | 9/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.45 |
| ▸ | PIM1 | P11309 | 5/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26095945 | 1.00 | DYRK2 (0.45) | DYRK2CDK5CDK5R1PIM1DYRK3 | |
| SCHEMBL26092710 | 0.82 | DYRK2 (0.44) | DYRK2CDK5CDK5R1PIM1DYRK3 | |
| SCHEMBL30494381 | 0.82 | DYRK2 (0.44) | DYRK2CDK5CDK5R1PIM1DYRK3 | |
| SCHEMBL30494070 | 0.79 | DYRK2 (0.46) | DYRK2CDK5CDK5R1PIM1DYRK3 | |
| SCHEMBL26093429 | 0.79 | DYRK2 (0.46) | DYRK2CDK5CDK5R1PIM1DYRK3 | |
| SCHEMBL26095593 | 0.79 | DYRK1A (0.49) | DYRK2CDK5CDK5R1PIM1DYRK3 | |
| SCHEMBL30494270 | 0.79 | DYRK1A (0.49) | DYRK2CDK5CDK5R1PIM1DYRK3 | |
| SCHEMBL30395543 | 0.78 | DYRK2 (0.49) | DYRK2CDK5CDK5R1PIM1DYRK3 | |
| SCHEMBL26092047 | 0.78 | DYRK2 (0.49) | DYRK2CDK5CDK5R1PIM1DYRK3 | |
| SCHEMBL26094360 | 0.78 | DYRK2 (0.45) | DYRK2CDK5CDK5R1PIM1DYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4422753-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2024-09-04 | — | — | EP | claimed |
| WO-2023072966-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-05-04 | — | — | WO | claimed |
| EP-4422753-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2024-09-04 | — | — | EP | disclosed |
| WO-2023072966-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-05-04 | — | — | WO | disclosed |