Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK2 | Q92630 | 12/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.40 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 7/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 5/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 3/20 | 0.34 |
| ▸ | CLK2 | P49760 | 3/20 | 0.34 |
| ▸ | GSK3A | P49840 | 2/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.34 |
| ▸ | DYRK4 | Q9NR20 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.34 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26091777 | 1.00 | DYRK2 (0.40) | DYRK2CDK5CDK5R1IP6K1PIM1 | |
| SCHEMBL26092651 | 1.00 | DYRK2 (0.40) | DYRK2CDK5CDK5R1IP6K1PIM1 | |
| SCHEMBL30494274 | 1.00 | DYRK2 (0.40) | DYRK2CDK5CDK5R1IP6K1PIM1 | |
| SCHEMBL26096001 | 1.00 | DYRK2 (0.40) | DYRK2CDK5CDK5R1IP6K1PIM1 | |
| SCHEMBL30494396 | 1.00 | DYRK2 (0.40) | DYRK2CDK5CDK5R1IP6K1PIM1 | |
| SCHEMBL26092677 | 0.89 | DYRK2 (0.39) | DYRK2CDK5CDK5R1PIM1DYRK3 | |
| SCHEMBL30494134 | 0.89 | DYRK2 (0.39) | DYRK2CDK5CDK5R1PIM1DYRK3 | |
| SCHEMBL30363324 | 0.84 | DYRK2 (0.42) | DYRK2CDK5CDK5R1IP6K1PIM1 | |
| SCHEMBL30363449 | 0.84 | DYRK2 (0.42) | DYRK2CDK5CDK5R1IP6K1PIM1 | |
| SCHEMBL26106475 | 0.84 | DYRK2 (0.42) | DYRK2CDK5CDK5R1IP6K1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4422753-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2024-09-04 | — | — | EP | claimed |
| WO-2023072966-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-05-04 | — | — | WO | claimed |
| EP-4422753-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2024-09-04 | — | — | EP | disclosed |
| WO-2023072966-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-05-04 | — | — | WO | disclosed |