Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 15/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | TPH2 | Q8IWU9 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24253642 | 1.00 | TPH1 (0.36) | TPH1HRH4FFAR1FFAR4TPH2 | |
| SCHEMBL30494553 | 0.93 | TPH1 (0.37) | TPH1HRH4FFAR1FFAR4TPH2 | |
| SCHEMBL24253748 | 0.93 | TPH1 (0.37) | TPH1HRH4FFAR1FFAR4TPH2 | |
| SCHEMBL30494551 | 0.89 | TPH1 (0.36) | TPH1HRH4FFAR1FFAR4TPH2 | |
| SCHEMBL24253852 | 0.87 | TPH1 (0.37) | TPH1HRH4FFAR1FFAR4TPH2 | |
| SCHEMBL30423886 | 0.87 | TPH1 (0.37) | TPH1HRH4FFAR1FFAR4TPH2 | |
| SCHEMBL24253649 | 0.86 | TPH1 (0.35) | TPH1TPH2 | |
| SCHEMBL24253760 | 0.84 | TPH1 (0.41) | TPH1TPH2 | |
| SCHEMBL24253761 | 0.84 | TPH1 (0.41) | TPH1TPH2 | |
| SCHEMBL24253553 | 0.84 | TPH1 (0.41) | TPH1TPH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4196478-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | Novartis AG (CH) | 2023-06-21 | — | — | EP | claimed |
| EP-4196478-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | Novartis AG (CH) | 2023-06-21 | — | — | EP | disclosed |