Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.46 |
| ▸ | PARP4 | Q9UKK3 | 4/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 3/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.44 |
| ▸ | CCR6 | P51684 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25361605 | 1.00 | PARP1 (0.46) | PARP1PARP4TNKS2MAPK1MEN1 | |
| SCHEMBL22101199 | 0.83 | PARP1 (0.47) | PARP1PARP4TNKS2L3MBTL1ALDH1A1 | |
| SCHEMBL22101275 | 0.79 | PARP4 (0.63) | PARP1PARP4TNKS2MAPK1MEN1 | |
| SCHEMBL30494981 | 0.78 | PARP1 (0.49) | PARP1PARP4TNKS2MAPK1MEN1 | |
| SCHEMBL25359756 | 0.78 | PARP1 (0.49) | PARP1PARP4TNKS2MAPK1MEN1 | |
| SCHEMBL22101365 | 0.76 | PARP1 (0.47) | PARP1PARP4TNKS2MAPK1MEN1 | |
| SCHEMBL25363387 | 0.72 | TNKS (0.58) | PARP1TNKS2MAPTALDH1A1PARP2 | |
| SCHEMBL17298077 | 0.72 | TNKS2 (0.64) | PARP1TNKS2MEN1KMT2ATDP1 | |
| SCHEMBL22101318 | 0.71 | PARP4 (0.44) | PARP1PARP4TNKS2MAPK1MEN1 | |
| SCHEMBL3927954 | 0.71 | PARP1 (0.70) | PARP1ALDH1A1PIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023159155-A1 | INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) AND USES THEREOF | PIVALENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |