Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 14/20 | 0.58 |
| ▸ | TNKS2 | Q9H2K2 | 14/20 | 0.58 |
| ▸ | PARP1 | P09874 | 7/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | PARP2 | Q9UGN5 | 5/20 | 0.51 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.49 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | GUSB | P08236 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27961710 | 0.86 | TNKS (0.55) | TNKSTNKS2PARP1RAB9ANPC1 | |
| SCHEMBL11826929 | 0.77 | TNKS (0.70) | TNKSTNKS2PARP1RAB9ANPC1 | |
| SCHEMBL30494981 | 0.75 | PARP1 (0.49) | TNKSTNKS2PARP1PARP2ALDH1A1 | |
| SCHEMBL25359756 | 0.75 | PARP1 (0.49) | TNKSTNKS2PARP1PARP2ALDH1A1 | |
| SCHEMBL15775476 | 0.74 | TNKS (1.00) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL30721036 | 0.73 | HTR3A (0.41) | PARP1RAB9APOLBKDM4EALDH1A1 | |
| SCHEMBL27385186 | 0.73 | HTR3A (0.41) | PARP1RAB9APOLBKDM4EALDH1A1 | |
| SCHEMBL25361605 | 0.72 | PARP1 (0.46) | TNKS2PARP1PARP2ALDH1A1MAPT | |
| SCHEMBL31163543 | 0.72 | PARP1 (0.50) | TNKSTNKS2PARP1RAB9ANPC1 | |
| SCHEMBL30495202 | 0.72 | PARP1 (0.46) | TNKS2PARP1PARP2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023159155-A1 | INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) AND USES THEREOF | PIVALENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |
| WO-2023159155-A1 | INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) AND USES THEREOF | PIVALENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |