Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | BTK | Q06187 | 5/20 | 0.41 |
| ▸ | PDE9A | O76083 | 2/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25230106 | 1.00 | KMT2A (0.42) | KMT2ABTKPDE9ADPP7MEN1 | |
| SCHEMBL21903828 | 0.91 | KMT2A (0.42) | KMT2ABTKPDE9ADPP7MEN1 | |
| SCHEMBL21903640 | 0.91 | KMT2A (0.42) | KMT2ABTKPDE9ADPP7MEN1 | |
| SCHEMBL21903644 | 0.91 | KMT2A (0.42) | KMT2ABTKPDE9ADPP7MEN1 | |
| SCHEMBL25649309 | 0.91 | BTK (0.41) | KMT2ABTKPDE9ADPP7SMN1; SMN2 | |
| SCHEMBL31125791 | 0.91 | BTK (0.41) | KMT2ABTKPDE9ADPP7SMN1; SMN2 | |
| SCHEMBL27217920 | 0.88 | ERBB2 (0.44) | KMT2ABTKPDE9A | |
| SCHEMBL21903785 | 0.87 | BTK (0.52) | BTK | |
| SCHEMBL21903789 | 0.87 | BTK (0.52) | BTK | |
| SCHEMBL24651144 | 0.85 | NPC1 (0.43) | KMT2APDE9AMEN1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4448523-A1 | MACROCYCLIC BTK INHIBITORS | Crossfire Oncology Holding B.V. (NL) | 2024-10-23 | — | — | EP | disclosed |
| WO-2023110970-A1 | MACROCYCLIC BTK INHIBITORS | NETHERLANDS TRANSLATIONAL RESEARCH CENTER HOLDING B.V (NL) | 2023-06-22 | — | — | WO | disclosed |