Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Golvatinib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET known ✓ | P08581 | 10/20 | 1.00 |
| ▸ | KDR known ✓ | P35968 | 8/20 | 1.00 |
| ▸ | NTRK1 | P04629 | 2/20 | 1.00 |
| ▸ | EPHB6 | O15197 | 1/20 | 1.00 |
| ▸ | RIPK2 | O43353 | 1/20 | 1.00 |
| ▸ | ABL1 | P00519 | 1/20 | 1.00 |
| ▸ | LCK | P06239 | 1/20 | 1.00 |
| ▸ | LYN | P07948 | 1/20 | 1.00 |
| ▸ | RET | P07949 | 1/20 | 1.00 |
| ▸ | HCK | P08631 | 1/20 | 1.00 |
| ▸ | PDGFRB | P09619 | 1/20 | 1.00 |
| ▸ | BCR | P11274 | 1/20 | 1.00 |
| ▸ | EPHA2 | P29317 | 1/20 | 1.00 |
| ▸ | EPHB2 | P29323 | 1/20 | 1.00 |
| ▸ | FLT3 | P36888 | 1/20 | 1.00 |
| ▸ | ABL2 | P42684 | 1/20 | 1.00 |
| ▸ | FRK | P42685 | 1/20 | 1.00 |
| ▸ | LIMK1 | P53667 | 1/20 | 1.00 |
| ▸ | EPHB3 | P54753 | 1/20 | 1.00 |
| ▸ | EPHA5 | P54756 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Golvatinib SCHEMBL1727298 | 1.00 | MET (1.00) | METKDRNTRK1EPHB6RIPK2 | |
| Golvatinib SCHEMBL30498608 | 1.00 | MET (1.00) | METKDRNTRK1EPHB6RIPK2 | |
| Golvatinib SCHEMBL4249254 | 0.99 | MET (0.99) | METKDRNTRK1EPHB6RIPK2 | |
| Golvatinib SCHEMBL1727167 | 0.99 | MET (0.99) | METKDRNTRK1EPHB6RIPK2 | |
| SCHEMBL2250771 | 0.98 | MET (0.96) | METKDRNTRK1EPHB6RIPK2 | |
| Golvatinib SCHEMBL4245713 | 0.97 | MET (0.94) | METKDRNTRK1EPHB6RIPK2 | |
| Golvatinib SCHEMBL1728754 | 0.96 | MET (0.92) | METKDRNTRK1EPHB6RIPK2 | |
| Golvatinib SCHEMBL4248644 | 0.96 | MET (0.92) | METKDRNTRK1EPHB6RIPK2 | |
| Golvatinib SCHEMBL4251976 | 0.96 | MET (0.92) | METKDRNTRK1EPHB6RIPK2 | |
| Golvatinib SCHEMBL4248648 | 0.96 | MET (0.92) | METKDRNTRK1EPHB6RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2786750-B2 | AGENT FOR REDUCING ADVERSE SIDE EFFECTS OF KINASE INHIBITOR | EA PHARMA CO LTD (JP) | 2023-06-28 | — | — | EP | claimed |