⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15827025 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL3512729 | 0.97 | — | — | |
| SCHEMBL10357721 | 0.63 | — | — | |
| SCHEMBL213131 | 0.61 | MAPT (0.38) | — | |
| SCHEMBL9522678 | 0.60 | — | — | |
| SCHEMBL3618802 | 0.59 | — | — | |
| SCHEMBL5080954 | 0.57 | — | — | |
| SCHEMBL17533005 | 0.57 | — | — | |
| SCHEMBL4957 | 0.57 | — | — | |
| SCHEMBL1418135 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683034-B2 | Use of enzyme inhibitors of aminopeptidase N and/or dipeptidylpeptidase IV | IMTM GMBH (DE) | 2010-03-23 | — | — | US | claimed |
| CN-101284810-A | Cyano-pyrrolidine and cyano-tetrahydrothiazole derivates | YINLIN QIN (CN) | 2008-10-15 | — | — | CN | claimed |
| US-7291599-B2 | Use of inhibitors of enzymes having activities of amino peptidase N and/or dipeptidyl peptidase IV and of pharmaceutical preparations thereof for a therapy and prevention of chronical neurodegenerative diseases | KEYNEUROTEK AG (DE) | 2007-11-06 | — | — | US | claimed |
| US-7229969-B2 | Combinations of enzyme inhibitors and the use thereof | IMTM GMBH (DE) | 2007-06-12 | — | — | US | claimed |
| US-20070042938-A1 | Use of dpiv and apn inhibitors for the treatment of dermatalogical diseases involving the hyperproliferation and modified differentiation conditions of fibroblasts | IMTM GMBH (DE) | 2007-02-22 | — | — | US | claimed |
| CN-1819840-A | Use of inhibitors of enzymes with APN and/or DPIV activity and pharmaceutical preparations of said inhibitors for the treatment and prevention of dermatological diseases involving the hyperproliferati | INST MEDIZINTECHNOLOGIE MAGDEB (DE) | 2006-08-16 | — | — | CN | claimed |
| EP-1644033-A2 | USE OF INHIBITORS OF ENZYMES WITH AMINOPEPTIDASE N AND/OR DIPEPTIDYLPEPTIDASE IV ACTIVITY AND PHARMACEUTICAL PREPARATIONS OF SAID INHIBITORS FOR THE TREATMENT AND PREVENTION OF DERMATOLOGICAL DISEASES INVOLVING THE HYPERPROLIFERATION AND MODIFIED DIFFERENTIATION CONDITIONS OF FIBROBLASTS | IMTM GmbH (DE) | 2006-04-12 | — | — | EP | claimed |
| US-20060040850-A1 | Use of enzyme inhibitors with aminopeptidase n and/or dipeptidylpeptidase IV activities and pharmaceutical preparations produced therefrom for the therapy and prevention of dermatological diseases with seborrhoeic hyperproliferation and altered differentiation states | IMTM GMBH (DE) | 2006-02-23 | — | — | US | claimed |
| CN-1738636-A | Use of inhibitors of enzymes having aminopeptidase N and/or dipeptidylpeptidase IV activity for producing medicaments for treating and preventing skin diseases caused by excessive sebum proliferation and changes in differentiation state and pharmaceutical preparations containing the same | IMTM INST FUER MEDIZINTECHNOLO (DE) | 2006-02-22 | — | — | CN | claimed |
| EP-1289559-B1 | COMBINATIONS OF ENZYME INHIBITOR-CONTAINING PREPARATIONS AND THE USE THEREOF | INST MEDIZINTECHNOLOGIE MAGDEB (DE) | 2005-07-27 | — | — | EP | claimed |
| US-20040106802-A1 | Novel compounds and therapeutic uses thereof | TORRENT PHARMACEUTICALS LTD. | 2004-06-03 | — | — | US | claimed |
| CN-1501796-A | Treatment of type 2 diabetes mellitus using inhibitors of dipeptidyl peptidase IV | ���ֹɷݹ�˾ | 2004-06-02 | — | — | CN | claimed |
| EP-1377278-A1 | TREATMENT OF TYPE 2 DIABETES WITH INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | Ferring BV (NL) | 2004-01-07 | — | — | EP | claimed |
| US-20030225102-A1 | Novel compounds and therapeutic uses thereof | TORRENT PHARMACEUTICALS LTD. | 2003-12-04 | — | — | US | claimed |
| WO-2003084940-A1 | THIAZOLIDINE-4-CARBONITRILES AND ANALOGUES AND THEIR USE AS DIPEPTIDYL-PEPTIDAS INHIBITORS | SANKARANARAYANAN ALANGUDI (IN) | 2003-10-16 | — | — | WO | claimed |
| EP-0861246-B1 | PROLYL ENDOPEPTIDASE INHIBITORS, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | SANDOR ERDOE DR (HU) | 2003-10-15 | — | — | EP | claimed |
| WO-2002083109-A1 | TREATMENT OF TYPE 2 DIABETES WITH INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | FERRING BV (NL) | 2002-10-24 | — | — | WO | claimed |
| EP-0861246-A1 | PROLYLENDOPEPTIDASE INHIBITORS | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1998-09-02 | — | — | EP | claimed |
| WO-1998035960-A1 | PROLYLENDOPEPTIDASE INHIBITORS | Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. (HU) | 1998-08-20 | — | — | WO | claimed |
| WO-1997007116-A1 | PROLYLENDOPEPTIDASE INHIBITORS | CHINOIN GYÓGYSZER ÉS VEGYÉSZETI (HU) | 1997-02-27 | — | — | WO | claimed |