Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 7/20 | 0.73 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.73 |
| ▸ | CDK2 | P24941 | 5/20 | 0.73 |
| ▸ | FLT3 | P36888 | 4/20 | 0.73 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.73 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.70 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.70 |
| ▸ | CDK9 | P50750 | 1/20 | 0.70 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.67 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.67 |
| ▸ | CDK7 | P50613 | 2/20 | 0.64 |
| ▸ | CCNH | P51946 | 2/20 | 0.64 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.64 |
| ▸ | JAK2 | O60674 | 3/20 | 0.63 |
| ▸ | RET | P07949 | 7/20 | 0.62 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | CDK4 | P11802 | 1/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.57 |
| ▸ | CDC7 | O00311 | 1/20 | 0.56 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3052850 | 0.89 | FLT3 (0.73) | CDK1CCNB1CDK2FLT3CCNE1 | |
| SCHEMBL3043740 | 0.85 | JAK2 (0.58) | CDK1CCNB1CDK2FLT3CCNE1 | |
| SCHEMBL13007934 | 0.84 | RET (0.84) | CDK1CCNB1CDK2FLT3CCNE1 | |
| SCHEMBL13086862 | 0.82 | JAK2 (0.59) | CDK1CCNB1CDK2FLT3CCNE1 | |
| SCHEMBL3052816 | 0.81 | JAK2 (0.56) | CDK1CCNB1CDK2FLT3CCNE1 | |
| SCHEMBL3052529 | 0.81 | JAK2 (0.58) | CDK1CCNB1CDK2FLT3CCNE1 | |
| SCHEMBL3049599 | 0.81 | JAK2 (0.60) | CDK1CCNB1CDK2FLT3CCNE1 | |
| SCHEMBL3035592 | 0.81 | JAK2 (0.66) | FLT3CCNT1CDK9JAK2 | |
| SCHEMBL2544992 | 0.81 | CCNB2 (1.00) | CDK1CCNB1CDK2CCNT1CCNA2 | |
| SCHEMBL3044992 | 0.81 | JAK2 (0.55) | CDK1CCNB1CDK2FLT3CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100267707-A1 | Tyrosine Kinase Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-10-21 | — | — | US | claimed |
| EP-2040546-A2 | TYROSINE KINASE INHIBITORS | Merck & Co., Inc. (US) | 2009-04-01 | — | — | EP | claimed |
| WO-2007149427-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2007-12-27 | — | — | WO | claimed |
| US-20100267707-A1 | Tyrosine Kinase Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-10-21 | — | — | US | disclosed |
| US-20100267707-A1 | Tyrosine Kinase Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-10-21 | — | — | US | disclosed |
| US-20100267707-A1 | Tyrosine Kinase Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-10-21 | — | — | US | disclosed |
| EP-2040546-A2 | TYROSINE KINASE INHIBITORS | Merck & Co., Inc. (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2007149427-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2007-12-27 | — | — | WO | disclosed |
| WO-2007149427-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2007-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267707-A1 | Tyrosine Kinase Inhibitors | ABL1, ERBB2, MET | CDK1 178/4885CCNB1 943/4885CDK2 145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.