Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | LGMN | Q99538 | 3/20 | 0.37 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 2/20 | 0.37 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.36 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.36 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30501443 | 0.92 | CDK2 (0.40) | PRKCAPRKCQCDK2GSK3BIRAK4 | |
| SCHEMBL30501359 | 0.91 | IRAK4 (0.45) | CDK2GSK3BIRAK4PIK3CDCCNA2 | |
| SCHEMBL30501446 | 0.91 | IRAK4 (0.46) | CDK2GSK3BIRAK4PIK3CDCCNA2 | |
| SCHEMBL30501447 | 0.88 | PIK3CD (0.41) | PRKCAPRKCQCDK2GSK3BIRAK4 | |
| SCHEMBL30501226 | 0.87 | CDK2 (0.42) | PRKCAPRKCQCDK2GSK3BIRAK4 | |
| SCHEMBL30501415 | 0.86 | CDK2 (0.40) | PRKCAPRKCQCDK2GSK3BPIK3CD | |
| SCHEMBL30501200 | 0.84 | IRAK4 (0.46) | CDK2GSK3BIRAK4PIK3CDCCNA2 | |
| SCHEMBL30501373 | 0.84 | CDK2 (0.39) | CDK2GSK3BIRAK4CCNA2CCNA1 | |
| SCHEMBL30501341 | 0.83 | JAK2 (0.45) | CDK2GSK3BIRAK4CCNA2CCNA1 | |
| SCHEMBL30501205 | 0.82 | CSF1R (0.41) | GSK3BIRAK4LRRK2CHEK1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032642-B | Kinase inhibitors and methods of making and using the same | 里格尔药品股份有限公司 | 2023-07-18 | — | — | CN | claimed |
| CN-111032642-B | Kinase inhibitors and methods of making and using the same | 里格尔药品股份有限公司 | 2023-07-18 | — | — | CN | disclosed |