Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 8/20 | 0.49 |
| ▸ | CCNC | P24863 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.40 |
| ▸ | INSR | P06213 | 2/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30501230 | 0.94 | CHEK1 (0.48) | CHEK1CCNCCDK8CDK19IRAK4 | |
| SCHEMBL30501210 | 0.88 | IRAK4 (0.42) | CHEK1IRAK4HDAC6 | |
| SCHEMBL30501446 | 0.86 | IRAK4 (0.46) | CHEK1IRAK4HDAC6 | |
| SCHEMBL30501208 | 0.86 | IRAK4 (0.43) | CHEK1CCNCCDK8CDK19IRAK4 | |
| SCHEMBL30501359 | 0.85 | IRAK4 (0.45) | CHEK1IRAK4HDAC6 | |
| SCHEMBL30501245 | 0.85 | SCN9A (0.42) | CHEK1CCNCCDK8CDK19IRAK4 | |
| SCHEMBL30501204 | 0.84 | TBK1 (0.44) | CHEK1CCNCCDK8CDK19CDK7 | |
| SCHEMBL30501388 | 0.84 | JAK2 (0.44) | IRAK4GRM2 | |
| SCHEMBL30501345 | 0.83 | CHEK1 (0.43) | CHEK1CCNCCDK8CDK19IRAK4 | |
| SCHEMBL30501355 | 0.83 | IRAK4 (0.45) | IRAK4ROCK2ROCK1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032642-B | Kinase inhibitors and methods of making and using the same | 里格尔药品股份有限公司 | 2023-07-18 | — | — | CN | disclosed |